杞黄颗粒对肝肾阴虚型年龄相关性黄斑变性视力及眼底情况的影响

发布时间：2018-01-16 15:34

  本文关键词：杞黄颗粒对肝肾阴虚型年龄相关性黄斑变性视力及眼底情况的影响　出处：《辽宁中医杂志》2017年02期 　论文类型：期刊论文

  更多相关文章： 杞黄颗粒 年龄相关性黄斑变性 视力 眼底情况

【摘要】：目的:探讨杞黄颗粒对年龄相关性黄斑变性(AMD)患者视力及眼底情况,如色素上皮脱失情况、玻璃膜疣、新生血管及出血量的影响。方法:采用随机平行对照研究,将2010年6月—2014年6月在广东省中医院眼科及天津中医药大学第一附属医院眼科就诊的肝肾阴虚型年龄相关性黄斑变性患者随机分为实验组及对照组。最终入组120例患者,治疗组62例,予以杞黄颗粒口服;对照组58例,予以维生素C口服。治疗前后均对患者双眼视力及眼底情况进行记录,经过14周服药后,采用t检验和卡方检验对数据进行组间及组内的对比。结果:治疗前后两组组间患者总体视力差异无统计学意义(P0.05),治疗前后两组组内对比有差异(P0.05);干性AMD治疗前后视力的组间比较,差异均具有统计学意义(P0.05),干性AMD治疗前后视力的组内比较,差异均具有统计学意义(P0.05);湿性AMD治疗前后视力的组间比较,差异均具有统计学意义(P0.05),湿性AMD治疗前后视力的组内比较,差异均具有统计学意义(P0.05);干性AMD患者的眼底色素上皮及玻璃膜疣治疗前,组间比较差异无统计学意义(P0.05),治疗后两组组间比较差异有统计学意义(P0.05),治疗前后两组组内对比,差异有统计学意义(P0.05);湿性AMD患者的的眼底出血及新生血管治疗前后,组间比较差异无统计学意义(P0.05),治疗前后两组组内对比,差异有统计学意义(P0.05)。结论:杞黄颗粒和维生素C对肝肾阴虚型年龄相关性黄斑变性的总体视力均有改善作用,且两者疗效相当;杞黄颗粒和维生素C对于干性AMD或湿性AMD患者的视力均有一定的改善作用;杞黄颗粒和维生素C均可改善干性AMD及湿性AMD患者的眼底情况,对于干性AMD患者眼底色素上皮及玻璃膜疣改善情况,两者疗效有差异,对于湿性AMD患者眼底出血及新生血管眼底改善情况,两者疗效相当;对于个别指标治疗前组间对比存在差异,考虑因患者个体差异所致,仍符合随机分组原则,对实验结果无影响。
[Abstract]:Objective: To investigate the effect of Qihuang Granule on age-related macular degeneration (AMD) patients with visual acuity and eye fundus, such as pigment epithelial loss, drusen, effects of neovascularization and hemorrhage. Methods: a randomized controlled study, June 2010 - June 2014 in Guangdong Province Traditional Chinese Medical Hospital and First Hospital Affiliated to Tianjin Medical University for treatment of liver and kidney yin deficiency age-related macular degeneration patients were randomly divided into experimental group and control group. 120 patients were enrolled, 62 cases in the treatment group were given oral Qihuang granule; 58 cases in the control group, given vitamin C orally. Before and after treatment in patients with binocular vision and fundus were recorded after 14 weeks after treatment, by t test and chi square test were compared between groups and within groups of data. Results: there was no significant difference between the two groups before and after treatment in patients with overall visual acuity differences (P0.05) before and after treatment, two Group comparison difference (P0.05) before and after AMD treatment; dry eye group comparison, the differences were statistically significant (P0.05) before and after AMD treatment, dry vision within the groups, the differences were statistically significant (P0.05); AMD group before and after treatment of visual wet between comparison, the differences were statistically meaning (P0.05), compared with AMD group before and after treatment of visual wet, the differences were statistically significant (P0.05); retinal pigment epithelium and drusen treatment of dry AMD patients, there was no significant difference between groups (P0.05), after treatment between the two groups was statistically significant (P0.05), before and after treatment in the two groups compared, the difference was statistically significant (P0.05); before and after wet AMD patients of retinal hemorrhage and neovascular treatment, there was no significant difference between groups (P0.05), comparing the two groups before and after treatment, the difference was statistically significant (P0.05 ). Conclusion: to improve the overall visual acuity of Qihuang granule and vitamin C on liver and kidney yin deficiency type of age-related macular degeneration, and the effects are nearly the same; Qihuang granule and vitamin C in patients with dry or wet AMD AMD visual acuity improved; Qihuang granule and vitamin C can improve the condition of dry eye AMD and wet AMD patients, AMD patients with retinal pigment epithelium for dry and drusen improvement, there are differences in efficacy for patients with wet AMD fundus hemorrhage and fundus neovascular improvement, two considerable effect on these differences; comparison between groups on individual indicators before treatment, due to considering the differences between patients. Is still in accordance with the principle of randomization, had no effect on the experimental results.

【作者单位】： 天津中医药大学;天津中医药大学第一附属医院;广州中医药大学第二附属医院;
【基金】：国家自然科学基金面上项目(81173308)
【分类号】：R276.7
【正文快照】： 老年性黄斑变性又称年龄相关的黄斑变性(age-relatedmaeulardegeneration,AMD),是以累及视网膜色素上皮(RPE)、感光细胞层和脉络膜多层组织为主的一种严重致盲性眼病。在美国仅1995年就有170万患者,其中10万人因此致盲。Framingham眼病研究中表明,在美国65~74岁的人群中,AMD发，

本文编号：1433735