益气养阴活血方对糖尿病脑梗死患者SDF-1水平影响的研究

发布时间：2018-01-16 17:03

本文关键词：益气养阴活血方对糖尿病脑梗死患者SDF-1水平影响的研究　出处：《中国地方病防治杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的观察益气养阴活血方对糖尿病脑梗死患者SDF-1水平的影响,探讨其对糖尿病脑梗死的干预机制。方法选取2型糖尿病合并脑梗死患者共60例,随机分成治疗组30例,对照组30例。对照组给予常规西药治疗,治疗组在西药治疗的基础上加服中药益气养阴活血方,在治疗终点应用统计学方法分析两组患者SDF-1水平的变化及临床疗效。结果治疗组患者血浆SDF-1浓度(124.91±20.53)pg/ml较对照组(105.8±25.03)pg/ml明显升高,治疗组低密度脂蛋白胆固醇(1.17±0.55)mmol/L较对照组(1.83±0.53)mmol/L明显下降、治疗组糖化血红蛋白水平(4.86±0.85)%较对照组(5.6±0.88)%明显下降,差异有统计学意义(P0.05)。结论益气养阴活血方加西药基础治疗糖尿病脑梗死,能够降低血浆低密度脂蛋白胆固醇、糖化血红蛋白水平,减轻脑血管病变,疗效显著,具有重要的临床意义。
[Abstract]:Objective to observe the effect of Yiqi Yangyin Huoxue recipe on SDF-1 level in patients with diabetic cerebral infarction and to explore its intervention mechanism. Methods 60 patients with type 2 diabetes mellitus complicated with cerebral infarction were selected. The control group was treated with routine western medicine, the treatment group was treated with western medicine, and the treatment group was treated with traditional Chinese medicine for supplementing qi and nourishing yin and activating blood circulation. At the end of the treatment, the changes of SDF-1 level and the clinical efficacy were analyzed by statistical method. Results the plasma SDF-1 concentration was 124.91 卤20.53 in the treatment group. Pg/ml was significantly higher than that of control group (105.8 卤25.03g / ml). The low density lipoprotein cholesterol (LDL-C) in the treatment group was significantly lower than that in the control group (1.17 卤0.55 mmol / L vs 1.83 卤0.53 mmol / L). The level of glycosylated hemoglobin in the treatment group (4.86 卤0.85) was significantly lower than that in the control group (5.6 卤0.88). Conclusion Yiqi Yangyin Huoxue prescription combined with western medicine can reduce plasma low density lipoprotein cholesterol and glycosylated hemoglobin level in the treatment of diabetic cerebral infarction. Reduce cerebrovascular disease, the curative effect is remarkable, has the important clinical significance.
【作者单位】：苏州大学附属第一医院;
【基金】：苏州市科学技术局医疗卫生应用基础研究项目,编号:SYSD2016177
【分类号】：R259;R277.7
【正文快照】： 糖尿病脑梗死属中医学中的“消渴”“中风”范畴,中医对消渴病的认识有着悠久的历史,早在《黄帝内经》就有“消渴”这个病名,《素问·奇病论》中“脾瘅,此人必数食甘美而多肥也,肥者令人内热,甘者令人中满,故其气上溢,转为消渴”[1-3]。《证治要诀·消瘅》“三消日久,精血既亏

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