温潜法治疗慢性失眠虚阳上扰证临床疗效观察

发布时间：2018-01-17 02:09

本文关键词：温潜法治疗慢性失眠虚阳上扰证临床疗效观察　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:运用温潜法,以潜阳安神汤加减联合佐匹克隆治疗慢性失眠虚阳上扰证患者,多方面观察其临床疗效,并进行理论探讨,为中医药治疗失眠提供新思路及方法。方法:采取随机化分组的原则,将入选的70例患者,随机分为中药联合佐匹克隆试验组和佐匹克隆对照组,两组各35例。两组疗程均为4周。治疗结束后判定临床疗效,并观察匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)、Flinders疲劳量表(Flinders Fatigue Scale,FFS)、抑郁自评量表(Self-Rating Depression Scale,SDS)、焦虑自评量表(Self-Rating Anxiety Scale,SAS)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)、虚阳上扰证症状分级量表的评分变化情况,随时记录治疗过程中出现的不良反应情况。结果:因部分患者依从性差而导致5例病例脱落,最终分析病例为65例,试验组33例,对照组32例。治疗后,两组疗效经等级秩和检验,P=0.0360.05,试验组总有效率为93.9%,对照组为75%,试验组有效率高于对照组。试验组在降低匹兹堡睡眠质量指数、Flinders疲劳量表、抑郁自评量表、焦虑自评量表、虚阳上扰证症状分级量表评分方面均优于对照组(P0.05或0.01)。两组在提高蒙特利尔认知评估量表评分方面未有明显差异。试验组未发生明显不良反应。结论:以阳虚失眠为理论基础,温潜法为基本治法,运用潜阳安神汤加减联合佐匹克隆治疗慢性失眠虚阳上扰证具有较好的临床疗效,有利于患者提高睡眠效率、减轻日间疲劳及焦虑、抑郁情绪,改善腰膝酸软、神疲倦怠、烦躁、心悸心慌、多汗、浮肿、耳鸣、大便稀症状,且无明显不良反应,使患者的生存质量得以提高。
[Abstract]:Objective: to observe the clinical effect of QYANS combined with Zopicron in the treatment of chronic insomnia with deficiency of yang and disturbance of yang in many aspects, and to explore its theory. Methods: 70 patients were randomly divided into Chinese medicine combined with zopicron test group and zopicron control group. There were 35 cases in each group. The course of treatment in both groups was 4 weeks. The Pittsburgh Sleep Quality Index (PSQI) was also observed. Flinders fatigue scale (FFSs). Self-Rating Depression scale (SDSs). Self-Rating Anxiety scale (SAS). The scores of Montreal Cognitive Assessment scale (Montreal Cognitive Assessment scale) and the symptom scale of deficiency and Yang disturbance (DYS) were evaluated by Montreal Cognitive Assessment scale (MCAA). Results: 5 cases fell off due to the poor compliance of some patients, 65 cases were analyzed, 33 cases in the test group and 32 cases in the control group. After rank sum test, the total effective rate of the two groups was 93.9 and that of the control group was 75%. The effective rate of the trial group was higher than that of the control group. The experimental group was reducing Pittsburgh Sleep quality Index Flinders fatigue scale, Self-Rating Depression scale, and Self-Rating anxiety scale. The score of the symptom scale of deficiency yang upper disturbance syndrome was better than that of the control group (P0.05 or 0.01). There was no significant difference between the two groups in improving the score of Montreal Cognitive Assessment scale. There was no significant adverse reaction in the test group. Conclusion: the theory is based on yang deficiency insomnia. Wenqian method is the basic treatment, using Qianyang Anshen decoction combined with Zopicron to treat chronic insomnia deficiency and yang disturbance syndrome has a good clinical effect, is conducive to improve the sleeping efficiency of patients, reduce daytime fatigue and anxiety. Depression mood, improving waist and knee weakness, fatigue, irritability, palpitation, sweating, swelling, tinnitus, stool, and no obvious adverse reaction, so that the patient's quality of life can be improved.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.23

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