电针对高血压病前期大鼠Toll样受体4信号通路的影响

发布时间：2018-01-20 14:41

本文关键词： 高血压病前期电针 Toll样受体信号通路肿瘤坏死因子受体相关因子- 转录激活因子蛋白- 足三里曲池　出处：《中华中医药杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的:通过电针高血压病前期大鼠足三里、曲池穴,观察其脾脏中Toll样受体4(TLR4)信号通路中TLR4、肿瘤坏死因子受体相关因子-6(TRAF-6)、转录激活因子蛋白-1(AP-1)基因的表达情况。方法:10只盐抵抗大鼠为正常组;30只Dahl盐敏感大鼠分为模型组、针刺组、非经非穴组。先采用高盐饲养,当血压升高至高血压病前期水平时,电针治疗并改为普通饲料饲养,当血压恢复正常时,停止针刺并取材,检测各基因表达情况。结果:电针刺激后,与模型组相比,针刺组TLR4、TRAF-6、AP-1的m RNA基因表达均显著降低(P0.05)。结论:针刺可有效改善高血压病前期大鼠免疫功能紊乱。
[Abstract]:Objective: to observe the TLR4 in the signal pathway of Toll like receptor 4 (TLR4) in the spleen by electroacupuncture at Zusanli and Quchi points in the prehypertensive rats. The expression of tumor necrosis factor receptor-associated factor (TNF- 6) TRAF-6, transcriptional activator protein (TNF- 1) AP-1.Methods Ten salt-resistant rats were used as normal control group. Thirty Dahl salt sensitive rats were divided into three groups: model group, acupuncture group and non-acupoint group. When the blood pressure returned to normal, the acupuncture group was stopped and the samples were obtained, and the expression of each gene was detected. Results: after electroacupuncture stimulation, compared with the model group, the acupuncture group TLR4 + TRAF-6 was compared with the model group. The expression of m RNA gene in AP-1 decreased significantly (P 0.05). Conclusion: acupuncture can effectively improve the immune dysfunction in prehypertensive rats.
【作者单位】：辽宁中医药大学杏林学院;
【分类号】：R245
【正文快照】： 近年来,众多学者认为高血压病前期时机体内存在并未达到疾病诊断标准的细微的病理变化。有研究发现,在高血压病血压开始升高的前10年甚至更长一段时间,动脉血管壁尤其是小动脉壁已经出现中层增厚。JNC在2003年定义高血压病前期血压值为收缩压120-139mm Hg和(或)舒张压80-89mm

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