疏肝和胃法治疗肝胃不和型胆汁反流性胃炎的临床疗效

发布时间：2018-01-20 14:19

本文关键词： 胆汁反流性胃炎疏肝和胃肝胃不和证临床疗效　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察疏肝和胃法治疗肝胃不和型胆汁反流性胃炎的临床疗效。方法：本研究搜集胆汁反流性胃炎(Bile reflux gastritis)病例44例,且同时中医辨证符合肝胃不和型,将其随机分为治疗组和对照组各22例,两组患者在性别、年龄、病程、病情包括治疗前胃镜下胆汁反流程度及治疗前中医症状总积分上无明显差异,具有可比性(p0.05)。分别予以治疗组中药疏肝和胃法进行治疗,每日1剂,早晚分服；予以对照组莫沙比利分散片5mg,每日3次,饭前30分钟口服,奥美拉唑胶囊20mg,于每日早晨起床后及晚上睡前口服。以4周为1疗程,两组疗程均为2个疗程。治疗期间分别观察和记录患者的临床症状及体征,2个疗程结束后对两组的结果进行比较,分别比较两组总疗效、治疗后中医临床症状改善情况、中医症状总积分来作出综合评定。采用SPSS 17.0统计软件进行数据统计,计量资料用“均数±标准差”(x±s)表示,首先进行正态性和方差齐性检验,若检验符合正态分布且方差齐,则组内比较采用配对t检验,而组间比较采用完全随机设计的成组t检验。若为非正态分布、方差不齐,采用非参数检验(秩和检验)。计数资料用例数表示,采用x2检验。等级资料用秩和检验。P0.05为差异有统计学意义。结果：1.两疗程过后,两组总有效率结果为治疗组86.36%,对照组77.27%,可见BRG中药治疗组疗效优于西药对照组,差异有统计学意义(P0.05)。2.在改善中医总体证候积分上,治疗组疗效均优于对照组(P0.05)。3.对于各症状而言,治疗组可明显改善除口苦外的其他症状,而对照组对于烧心、善太息、不欲食、精神抑郁均无明显改善作用。结论：疏肝和胃法在治疗肝胃不和型BRG的临床疗效可靠,未见明显不良反应,安全性高,同时能够较为明显的改善患者的生活质量。
[Abstract]:Objective: to observe the clinical efficacy of the method of soothing the liver and stomach in the treatment of hepatogastric disharmony bile reflux gastritis. Methods: this study collected the bile reflux gastritis (Bile reflux gastritis). 44 cases. At the same time, TCM syndrome differentiation accords with the type of disharmony of liver and stomach, and it is randomly divided into treatment group and control group, 22 cases each, the two groups of patients in gender, age, course of disease. There was no significant difference in the degree of bile reflux under gastroscope before treatment and the total score of TCM symptoms before treatment. The patients in the treatment group were treated with traditional Chinese medicine to soothe the liver and stomach respectively. Take 1 dose daily, morning and evening; The control group was given 5 mg of moxapride dispersible tablets 3 times a day 30 minutes before meal and 20 mg of omeprazole capsule. The patients were taken orally after getting up in the morning and before going to bed in the evening. The course of treatment was 4 weeks. The clinical symptoms and signs of the two groups were observed and recorded during the treatment, and the results of the two groups were compared after the two courses of treatment, and the total curative effects of the two groups were compared respectively. After treatment, the clinical symptoms of TCM were improved, and the total score of TCM symptoms was evaluated. The statistical software SPSS 17.0 was used for statistical analysis. The measurement data were expressed as "mean 卤standard deviation" (x 卤s). First, the homogeneity test of normality and variance was carried out. If the test was consistent with normal distribution and the variance was homogeneous, the matched t test was used in the comparison within the group. In the case of non-normal distribution and uneven variance, non-parametric test (rank sum test) was used. The counting data were represented by the number of cases. Using x2 test. Grade data with rank sum test. P0.05 as the difference was statistically significant. Results: 1. After two courses of treatment, the total effective rate of the two groups was 86.36%. The control group 77.27 can be seen that the BRG traditional Chinese medicine treatment group is better than the western medicine control group, the difference is statistically significant in improving the integral of the overall syndromes of traditional Chinese medicine (TCM). The curative effect of the treatment group is better than that of the control group (P 0.05N. 3). For each symptom, the treatment group can obviously improve the other symptoms except bitter mouth, while the control group has the advantages of heartburn, good information and no desire to eat. Conclusion: the method of soothing the liver and stomach in the treatment of hepatogastric disharmony type BRG has a reliable clinical effect, no obvious adverse reactions, and high safety. At the same time, it can obviously improve the quality of life of patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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