加味柴胡疏肝散联合黛力新治疗肝郁气滞型功能性腹痛综合征的临床研究

发布时间：2018-01-24 10:10

本文关键词： 功能性腹痛综合征肝郁气滞型黛力新加味柴胡疏肝散　出处：《南京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察加味柴胡疏肝散联合黛力新对肝郁气滞型功能性腹痛综合征(FAPS)患者的临床症状及焦虑、抑郁状态的改善情况。挖掘中西医结合治疗FAPS患者的优势,为临床应用及推广提供更多依据。方法:收集2016年3月至2016年12月在昆山市中医院脾胃肝胆科门诊及病房确诊为肝郁气滞型功能性腹痛综合征的患者60例。随机分为对照组和治疗组各30例,对照组予氟哌噻吨美利曲辛片每日一片口服,实验组在对照组基础上加予加味柴胡疏肝散煎服。两组均治疗4周,记录治疗前后症状评分及焦虑抑郁积分,观察对比两组的治疗效果,并进行统计学分析。结果:(1)疼痛改善情况:两组组间治疗后经秩和检验,P=0.020(P0.05),差异具有统计学意义,证明治疗组在缓解疼痛症状方面的效果更优越。(2)中医症状改善情况:治疗组总有效率为86.7%,对照组为73.3%,对治疗前后中医疗效及中医症候总积分进行分析比较,治疗后两组间的差异有显著的统计学意义(P0.01),证明治疗组在缓解中医症状方面较对照组具有显著的优势。其中腹痛、两胁胀痛、食欲减退、嗳气四项症候的疗效两组比较差异有统计学意义(P0.05),证明治疗组在缓解这几项症候方面相较对照组更有效。而对于失眠多梦,经分析得出P=0.521(P0.05),差异无统计学意义,治疗组与对照组疗效相当。(3)焦虑抑郁改善情况:通过比较治疗前后SAS、SDS积分变化,治疗组与对照组之间的差异具有统计学意义(P0.05),故认为治疗组在改善焦虑、抑郁方面疗效更佳。结论:运用加味柴胡疏肝散联合黛力新能有效改善肝郁气滞型FAPs患者的临床症状以及焦虑抑郁的心理状态,在临床中值得推广与应用。
[Abstract]:Objective: to observe the clinical symptoms and anxiety of Jiawei Chaihu Shugan San combined with Delixin in patients with functional abdominal pain syndrome of liver stagnation and qi stagnation. To explore the advantages of integrated traditional Chinese and western medicine in the treatment of FAPS patients. To provide more evidence for clinical application and promotion. Methods:. From March 2016 to December 2016, 60 patients diagnosed as functional abdominal pain syndrome of stagnation of qi and liver-qi type in outpatient department and ward of spleen, stomach and hepatobiliary department of traditional Chinese medicine hospital of Kunshan City were collected. They were randomly divided into two groups: control group and treatment group. 30 cases. The control group was treated with droperazothioate meritriaxine tablets once a day, the experimental group was treated with modified Chaihu Shugan Powder decoction on the basis of the control group. Both groups were treated for 4 weeks, the symptom score and anxiety and depression score were recorded before and after treatment. Observation and comparison of the therapeutic effects of the two groups, and statistical analysis. Results: 1) pain improvement: after the treatment between the two groups after the rank sum test, P0. 020 and P0. 05). The difference was statistically significant, which proved that the treatment group had better effect in relieving pain symptoms. 2) the improvement of TCM symptoms: the total effective rate of treatment group was 86.7, and that of control group was 73.3%. Before and after the treatment of TCM curative effect and the total integral of TCM symptoms were analyzed and compared, the difference between the two groups after treatment has significant statistical significance (P 0.01). It is proved that the treatment group has a significant advantage over the control group in alleviating the symptoms of traditional Chinese medicine, in which abdominal pain, two hypochondriac pain, anorexia and belching are significantly different between the two groups (P 0.05). It is proved that the treatment group is more effective than the control group in alleviating these symptoms. However, for insomnia and dream, the analysis shows that there is no significant difference between the treatment group and the control group. The improvement of anxiety and depression in the treatment group was similar to that in the control group: the changes of SDS scores before and after treatment were compared. The difference between the treatment group and the control group was statistically significant (P 0.05), so it was considered that the treatment group was improving anxiety. Conclusion: the combination of modified Chaihu Shugan Powder and Delixin can effectively improve the clinical symptoms and anxiety and depression of patients with FAPs with liver depression and qi stagnation. It is worth popularizing and applying in clinic.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

【参考文献】