不同蜂针剂量治疗类风湿性关节炎大鼠的疗效研究

发布时间：2018-01-28 12:03

本文关键词： 蜂针类风湿性关节炎量效关系　出处：《辽宁中医杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:观察不同蜂针剂量对类风湿性关节炎大鼠疗效的影响。方法:将30只大鼠随机分为空白组、模型组和蜂针治疗4组(单蜂1 min组、双蜂1 min组、三蜂1 min组、单蜂30 s组),取足三里穴,连续治疗7 d。观察治疗前后体重、足趾容积、缩足反应时间及HE切片观察。结果:治疗后,与空白组比较,各组大鼠足趾容积提高,缩足反应时间下降,差异均有统计学意义(P0.05),体重改变没有显著差异。单蜂1 min组大鼠足趾容积低于其余各组,缩足反应时间高于其余各组,差异显著(P0.05)。结论:不同蜂针剂量对类风湿性关节炎大鼠均有一定治疗作用,其中单蜂1 min组近期疗效最显著。
[Abstract]:Objective: to observe the effect of different doses of bee needle on rheumatoid arthritis rats. Methods: 30 rats were randomly divided into blank group, model group and bee acupuncture treatment group (single bee 1 min group). The body weight and toe volume were observed before and after treatment at Zusanli point for 7 days. Results: compared with the blank group, compared with the blank group, the toe volume of rats in each group increased, the reaction time of foot contraction decreased, the difference was statistically significant (P 0.05). There was no significant difference in body weight change. The toe volume of single bee 1 min group was lower than that of other groups, and the reaction time of foot contraction was higher than that of other groups. Conclusion: different doses of bee needle have certain therapeutic effect on rheumatoid arthritis rats, and the short-term curative effect of single bee 1 min group is the most significant.
【作者单位】：南方医科大学中医药学院;南方医科大学中西医结合医院;
【基金】：国家自然科学基金(81303047) 广东省科学技术厅—广东省中医药科学院联合科研项目(2014A020221117)
【分类号】：R245
【正文快照】： 类风湿性关节炎(rheumatoid arthritis,RA)是一种慢性自身免疫性疾病,以周围关节对称性多关节炎为主要特征,容易侵犯关节滑膜、软骨等导致关节破坏,引起关节肿胀、疼痛,甚至关节畸形,影响关节功能。RA具有较高的发病率,且在地域和性别上存在一定的差异性。我国19个省市的调查

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