桃红四物汤对痰瘀互结型糖尿病合并动脉粥状硬化患者心率变异性、血脂及CRP的影响

发布时间：2018-02-01 13:52

本文关键词： 桃红四物汤痰瘀互结型糖尿病动脉粥状硬化心率变异性 C反应蛋白　出处：《中国实验方剂学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的:探讨桃红四物汤对痰瘀互结型糖尿病合并动脉粥状硬化患者心率变异性、血脂及C反应蛋白(CRP)的影响。方法:收集广东省中医院内科收治的痰瘀互结型糖尿病合并动脉粥状硬化患者120例,随机分为治疗组和对照组,各60例。2组患者均给予常规治疗,二甲双胍0.25 g·d-1,阿卡波糖50 mg·d~(-1)或注射胰岛素。对照组予以消心痛及复方丹参滴丸,10粒/次,每日1次口服;治疗组常规治疗基础上予以桃红四物汤加减,200 m L·d~(-1),分早晚2次温热后口服,每4周为1个疗程。2组均连续治疗4周。治疗结束后,比较患者心率变异性,血脂,血糖,CRP水平及不良反应发生情况。结果:治疗后与对照组比较,治疗组临床总有效率较高(P0.05)。与治疗前比较,两组患者24 h正常R-R间期的标准差(SDNN),相邻RR间期差值的均方根(RMSSD),相邻正常R-R间期差值50 ms比率(PNN50)水平升高(P0.05),与对照组比较,治疗组SDNN,RMSSD,PNN50水平较高(P0.05)。与治疗前比较,空腹血糖(FPG),餐后2 h血糖(PBG)以及糖化血红蛋白(Hb A1c)水平降低(P0.05);治疗后与对照组比较,治疗组FPG,PBG以及糖化血红蛋白水平较低(P0.05)。治疗后2组总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),甘油三酯(TG),CRP水平降低,高密度脂蛋白-胆固醇(HDL-C)升高(P0.05);与对照组比较,治疗组TC,LDL-C,TG水平较低,CRP,HDL-C水平较高(P0.05)。结论:桃红四物汤对痰瘀互结型糖尿病合并动脉粥状硬化患者的临床疗效显著,能够调节心率变异性,下调CRP水平,安全性高,适宜临床应用推广。
[Abstract]:Objective: to investigate the effect of Taohong Siwu decoction on heart rate variability in patients with phlegm-blood stasis syndrome diabetes complicated with atherosclerosis. Methods: 120 patients with phlegm-blood stasis syndrome diabetes complicated with porridge sclerosis were randomly divided into treatment group and control group. 60 patients in each group were given routine treatment with metformin 0.25 g 路d-1. The control group was given 10 tablets of isosorbide and compound salvia miltiorrhiza drop pills once a day. On the basis of routine treatment, the treatment group was treated with Taohong Siwu decoction plus or minus 200 mL 路dzhuan-1, which was taken orally after warm heat twice in the morning and evening. After the treatment, the patients' heart rate variability, blood lipid, blood glucose and CRP levels and adverse reactions were compared. Results: after the treatment, the patients were compared with the control group. The total clinical effective rate of the treatment group was higher than that of the control group (P 0.05). Compared with before treatment, the standard deviation of the 24 h normal R-R interval in the two groups was SDNN. The RMS SDN of RMS SDN and the ratio of PNN50 of adjacent normal R-R interval (RMS SDN) were higher than those of the control group (P 0.05). The level of RMS SDNN50 in the treatment group was higher than that in the control group (P 0.05). 2 h postprandial blood glucose (PBG) and glycosylated hemoglobin (HbA1c) decreased P0.05a; Compared with the control group, the levels of PBG and glycosylated hemoglobin in the treatment group were lower than those in the control group (P 0.05). Low density lipoprotein cholesterol (LDL-C), triglyceride triglyceride (TGN) and high density lipoprotein cholesterol (HDL-C) increased (P 0.05). Compared with the control group, the level of TG in the treatment group was lower than that in the control group. Conclusion: Taohong Siwu decoction has a significant clinical effect on patients with phlegm-blood stasis type diabetes mellitus complicated with atherosclerosis, which can regulate heart rate variability and down-regulate the level of CRP. It is safe and suitable for clinical application.
【作者单位】：广东省中医院;
【基金】：广东省中医药管理局立项项目(20131194)
【分类号】：R259
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170420.1125.060.html[网络出版时间]2017-04-20 11:25近年来糖尿病患者逐渐增多,我国糖尿病患者已超过9 000万人[1],是继心脑血管、肿瘤之后的第3大顽症,糖尿病患者主要死于心血管疾病,动脉粥状硬化是其主要的并

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