溃疡性结肠炎患者的血清S100A2含量及其与炎症程度、肠黏膜损伤的相关关系

发布时间：2018-02-05 02:01

本文关键词： 溃疡性结肠炎 SA 炎症程度肠黏膜损伤　出处：《中国中西医结合消化杂志》2017年01期 　论文类型：期刊论文

【摘要】：[目的]分析溃疡性结肠炎(UC)患者的血清S100A2含量及其与炎症程度、肠黏膜损伤的相关关系。[方法]2011年3月~2016年3月间在本院接受住院治疗的溃疡性结肠炎患者110例UC患者作为观察组,根据病情严重程度分为轻度组(n=45例)、中度组(n=35例)、重度组(n=30例),取同期在本院接受体检的健康人100例作为对照组。检测2组研究对象的血清S100A2及炎症因子含量,采用Weston-blot法测定肠黏膜损伤指标蛋白表达量。进一步采用Pearson检验分析溃疡性结肠炎患者血清S100A2含量及其与炎症程度、肠黏膜损伤的相关关系。[结果]观察组患者的血清S100A2,炎症因子C反应蛋白(CRP)、高迁移率族蛋白B1(HMGB1)、白介素-2(IL-2)、白介素-4(IL-4)、白介素-17(IL-17)含量均显著高于对照组,随着UC病情加重以上因子含量递增(P0.05);观察组患者的结肠黏膜Toll样受体4(TLR4)、细胞因子信号抑制子2(SOCS2)、细胞因子信号抑制子3(SOCS3)、树突状细胞表型分子(DC-SIGN)蛋白表达量均高于对照组,随着UC病情加重以上基因蛋白表达量递增(P0.05)。Pearson检验发现,UC患者的血清S100A2含量与炎症因子CRP、HMGB1、IL-2、IL-4、IL-17含量,肠黏膜损伤基因TLR4、SOCS2、SOCS3、DC-SIGN的蛋白表达量均呈正相关(P0.05)。[结论]溃疡性结肠炎患者的血清S100A2含量与病情严重程度直接相关,可以作为疾病早期诊断、治疗指导、预后评估的可靠手段。
[Abstract]:[Objective] to analyze the relationship between serum S100A2 level and inflammation degree and intestinal mucosal injury in patients with ulcerative colitis. [Methods: from March 2011 to March 2016, 110 patients with ulcerative colitis were treated in our hospital as the observation group. According to the severity of the disease, the patients were divided into mild group (n = 45), moderate group (n = 35), severe group (n = 30). The serum S100A2 and inflammatory factors were measured in 100 healthy persons who were examined in our hospital at the same time as control group. Weston-blot method was used to determine the expression of intestinal mucosal injury index protein. Further, Pearson test was used to analyze serum S100A2 level and its relationship with inflammation in patients with ulcerative colitis. . Correlation of intestinal mucosal injury. [Results: serum S100A2, inflammatory factor C-reactive protein (CRPN), high mobility group protein B1 (HMGB1), interleukin-2 (IL-2) were observed in the observation group. The contents of IL-4 and IL-17 were significantly higher than those of the control group, and the contents of the above factors increased with the exacerbation of UC. The colon mucosal Toll like receptor 4 (TLR4), cytokine signal suppressor 2 (SOCS2), cytokine signal suppressor 3 (SOCS3) were observed in the observation group. The expression of dendritic cell phenotypic molecule (DC-SIGN) protein was higher than that of the control group, and the expression of the above gene protein increased with the exacerbation of UC. The results of Pearson test showed that the expression of DC-SIGN protein was higher than that of the control group. The levels of serum S100A2 and inflammatory factor CRP- HMGB1 / IL-2IL-4 / IL-17, and the intestinal mucosal injury gene TLR4 / SOCS2 were measured in UC patients. The protein expression of DC-SIGN in SOCS3 was positively correlated with that of P0.05. [Conclusion: the serum S100A2 level in patients with ulcerative colitis is directly related to the severity of the disease, and can be used as a reliable means for early diagnosis, treatment guidance and prognosis evaluation of ulcerative colitis.
【作者单位】：浙江省嘉善县第一人民医院检验科;
【分类号】：R259
【正文快照】： 溃疡性结肠炎(Ulcerative colitis,UC)是病因不明的结肠、直肠慢性非特异性炎症性疾病,病程较长且反复发作,患者除血性腹泻、体重减轻、高热等典型表现外,远期还有癌变风险[1]。随着UC病程延长,患者临床症状加剧、癌变风险也倍增,早期确诊UC并判断病情严重程度是疾病治疗的关

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