吴氏扶阳流派学术思想诊治鼻鼽的理论探讨与临床应用研究

发布时间：2018-02-11 18:37

本文关键词： 吴氏扶阳流派学术思想鼻鼽阳虚型扶阳方变应性鼻炎　出处：《云南中医学院》2017年硕士论文　论文类型：学位论文

【摘要】：目的:1.归纳整理吴氏扶阳流派诊治鼻鼽(变应性鼻炎)的学术思想,总结吴氏扶阳流派诊治鼻鼽(变应性鼻炎)的理、法、方药。2.运用总结的吴氏扶阳流派扶阳方治疗阳虚型鼻鼽(变应性鼻炎)患者,观察其临床疗效,为临床推广应用提供有力证据。方法:1.理论研究方法通过文献检索及手工查寻等方法收集吴氏扶阳流派相关文献、著作,筛选吴氏扶阳流派学术思想诊治鼻鼽(变应性鼻炎)的相关文献。总结、提炼吴氏扶阳流派学术思想诊治鼻鼽(变应性鼻炎)的相关理论。2.临床研究方法收集60例阳虚型鼻鼽(变应性鼻炎)患者,按照随机分组法将病人随机分为治疗组和对照组。每组各30例。治疗组予扶阳方治疗,对照组予中成药《金匮肾气丸》治疗,疗程为两周。治疗后,对治疗前后的嗜酸粒细胞及症状体征评分运用统计学的方法评估疗效。结果:1.理论研究结果:通过大量数据资料和文献医案的研究,归纳整理吴氏扶阳流派诊治鼻鼽(变应性鼻炎)的学术思想,同时请教了吴氏扶阳流派传承人吴生元先生的意见,最终由导师周家璇教授确定治疗阳虚型鼻鼽(变应性鼻炎)的理、法、方药。2.临床研究结果2.1实验的60例研究对象,在性别、年龄、症状、体征等方面,比较无统计学差异,具有可比性。到治疗结束时脱落3例,剩余57例结果有效。其中治疗组29例,对照组28例。2.2治疗结束后,对57例有效样本进行统计分析:对照组总有效率:67.86%;治疗组总有效率:89.66%。对照组和治疗组治疗后症状体征总积分比较:t=-2.869,P=0.006,P0.01。两组比较差异性显著,有统计学意义。治疗组在改善打喷嚏、流清涕、鼻塞、鼻痒、乏力症状方面有极显著性差异,效果显著;在改善畏寒、自汗方面,有显著性差异;对照组在改善打喷嚏,流清涕、鼻塞、鼻痒、自汗等症状方面有极显著性差异,效果显著;在改善畏寒、乏力症状方面,无显著性差异。两组患者在改善鼻黏膜苍白、水肿方面,均有显著差异。在减少患者的鼻腔分泌物中嗜酸性粒细胞上,两组均有统计学意义,且治疗组较对照组效果更佳。2.3治疗前后的统计学评分比较,两组通过治疗后病情均有不同程度减轻,且治疗组优于对照组。结论:1.在本次实验中,吴氏扶阳学术思想可用于治疗阳虚型鼻鼽(变应性鼻炎)患者,在临床可以探索推广应用。2.总结的扶阳方通过临床研究发现治疗阳虚型鼻鼽(变应性鼻炎)有效,可以很好改善阳虚型鼻鼽(变应性鼻炎)患者鼻塞、流涕、喷嚏、畏寒、出汗、鼻痒、乏力及鼻黏膜肿胀等症状和体征,对患者鼻涕中嗜酸性粒细胞有一定的调节作用。3.临床安全性观察:在整个疗程中,治疗组与对照组均未发现不良反应病例。
[Abstract]:Objective\\\? Prescription medicine .2.Use the summarized Wu's Fu Yang school to treat the patients with allergic rhinitis with Yang deficiency type, and observe its clinical curative effect. To provide strong evidence for clinical popularization and application. Methods: 1. Theoretical research methods collect relevant literature and works of Wu's Fu Yang school through literature retrieval and manual search. To screen the literature on the diagnosis and treatment of allergic rhinitis by Wu Fuyang school. Abstract the relevant theories of Wu's Fu Yang School for the diagnosis and treatment of allergic rhinitis. 2. Clinical study methods collected 60 cases of allergic rhinitis with Yang deficiency type. The patients were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Fuyang prescription, while the control group was treated with traditional Chinese patent medicine (Jinkui Shenqi pills) for two weeks. The score of eosinophils and symptoms and signs before and after treatment was evaluated by statistical method. Results: 1. Theoretical study results: through a large number of data and medical documents, Summing up and sorting out the academic thoughts of Wu's Fu Yang school in the diagnosis and treatment of allergic rhinitis, and consulting the inheritor of Wu's Fu Yang school, Mr. Wu Shengyuan, Finally, Professor Zhou Jiaxuan, his mentor, determined the principles, methods, prescriptions and medicines for the treatment of allergic rhinitis of Yang deficiency type. There was no statistical difference in the sex, age, symptoms, signs and so on among the 60 experimental subjects in the clinical study results 2.1. By the end of the treatment, 3 cases had dropped out, the remaining 57 cases were effective. 29 cases in the treatment group and 28 cases in the control group. Statistical analysis of 57 effective samples: the total effective rate of the control group was: 67.866.The total effective rate of the treatment group was: 89.66.The total score of symptoms and signs after treatment in the control group and the treatment group was higher than that in the control group and the treatment group. The difference between the two groups was significant, and there was statistical significance between the two groups. There were significant differences in the symptoms of runny, nasal obstruction, itching and fatigue, significant difference in improving chills and sweating, and in the control group in improving sneezing, runny, stuffy, and itchy nose. There was significant difference in symptoms such as self-sweating, and there was no significant difference between the two groups in improving symptoms of chills and fatigue. In reducing eosinophils in nasal secretion of patients, there was statistical significance between the two groups, and the effect of treatment group was better than that of control group before and after treatment, and the score of eosinophils in the treatment group was better than that in the control group before and after treatment. The treatment group was superior to the control group. Conclusion 1. In this experiment, Wu Fuyang's academic thought can be used to treat the allergic rhinitis of Yang deficiency type. (2) in clinical practice, we can explore and popularize the application of Fuyang prescription. Through clinical studies, we find that Fuyang prescription is effective in treating allergic rhinitis with Yang deficiency type, and can improve nasal congestion, runny discharge, sneeze, and chills in patients with allergic rhinitis with Yang deficiency type. Sweating, itching, fatigue, swelling of nasal mucosa and other symptoms and signs, the eosinophils in nasal snot can be regulated to a certain extent .3.Clinical safety observation: in the whole course of treatment, no adverse reactions were found in the treatment group and the control group.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R276.1

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