503例乙肝后肝硬化中医证候特征的因子分析

发布时间：2018-02-16 09:43

本文关键词： 乙肝后肝硬化中医证素中医证候因子分析聚类分析　出处：《时珍国医国药》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨乙肝后肝硬化中医证素特点及证型分布规律。方法采集503例乙肝后肝硬化患者的四诊信息,运用因子分析与聚类分析方法相结合对61项变量进行分析,结合证素辨证体系寻找该病的中医证素特点及证型分布规律。结果证素辨证学研究结果得出本组503例乙肝后肝硬化病位证素5项,病性证素13项,其中病位证素主要涉及肝、脾、肾,病性证素主要涉及血瘀、气虚、气滞、湿热、水。采用因子分析61个证候条目,KMO统计量为0.812,Bartlett球型检验P0.0001,共提取出17个公因子,被提取有51项具有意义的症状,结合证素辨证学及专家讨论总结出7类中医证型:湿热内蕴证、脾肾阳虚证、肝肾阴虚证、肝郁脾虚证、脾虚湿盛证、血瘀证、脾气虚证。采用聚类分析出该病的证型分布比例,依次为血瘀证占24.85%(125/503),脾气虚证占19.28%(97/503),肝郁脾虚证14.91%(75/503),脾肾阳虚证占12.72%(64/503),湿热内蕴证占11.13%(56/503),脾虚湿盛证10.14%(51/503),肝肾阴虚证7.55%(38/503)。结论因子分析、聚类分析与证素辨证体系相结合用于乙肝后肝硬化证候特点研究,为该病的中医辨证分型客观化提供了一种新的方法和思路。
[Abstract]:Objective to investigate the characteristics of TCM syndromes and the distribution of syndromes in patients with posthepatitic cirrhosis of hepatitis B. methods the information of the four diagnoses of 503 patients with posthepatitic cirrhosis was collected and 61 variables were analyzed by factor analysis and cluster analysis. Combined with syndrome differentiation system, the characteristics of TCM syndromes and the distribution of syndromes were studied. Results the results of syndrome differentiation showed that there were 5 syndromes and 13 syndromes in 503 cases of posthepatitic liver cirrhosis, in which the syndrome factors were mainly related to liver. Spleen, kidney and disease syndrome factors are mainly related to blood stasis, deficiency of qi, stagnation of qi, dampness and heat, water. The statistical quantity of KMO of 61 syndromes by factor analysis is 0.812 Bartlett ball type test (P0.0001). 17 common factors were extracted and 51 significant symptoms were extracted. Combined with syndrome differentiation and expert discussion, seven types of TCM syndromes were summarized: internal damp-heat syndrome, spleen and kidney yang deficiency syndrome, liver and kidney yin deficiency syndrome, liver stagnation and spleen deficiency syndrome, spleen deficiency dampness syndrome, blood stasis syndrome, and so on. Spleen qi deficiency syndrome. The distribution ratio of syndrome type of spleen qi deficiency was analyzed by cluster analysis. The distribution proportion of syndrome type was 24.85g / 125 / 503n, 19.28g / 97 / 503n, 14.91n / 503n, 12.72264.64 / 503n, 11.1313N / 56503N, 10.1414N / 51503N, 7.555r-1 / 503N, respectively, respectively. Conclusion Factor analysis shows that the deficiency of spleen and kidney is 12.7264 / 56503N, and that of dampness and heat is 11.132n / 56503N, 10.1414N / 51503N, and that of deficiency of liver and kidney is 7.555r-1 / 5030.Conclusion Factor analysis is necessary. The combination of cluster analysis and syndrome differentiation system can be used to study the syndrome characteristics of liver cirrhosis after hepatitis B, which provides a new method and train of thought for the objectification of TCM syndrome differentiation and classification of the disease.
【作者单位】：陕西中医药大学;陕西中医药大学附属医院;
【基金】：陕西省咸阳市2014科技成果推广计划项目(No.2014KT-21) 陕西省教育厅科学技术研究项目(No.2010JK510) 陕西中医药大学附属医院课题(No.2014-35)
【分类号】：R259

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