养阴熄风胶囊治疗阴虚血瘀型脑梗塞合并2型糖尿病的临床研究

发布时间：2018-02-20 18:42

本文关键词： 养阴熄风胶囊脑梗塞合并2型糖尿病阴虚血瘀临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:观察养阴熄风胶囊治疗阴虚血瘀型脑梗塞合并2型糖尿病的临床疗效及临床应用的安全性,并根据中医药理论探讨阴虚血瘀型脑梗塞合并2型糖尿病的病因病机及养阴熄风胶囊治疗该病的作用机理。方法:将符合纳入标准的64例阴虚血瘀型脑梗塞合并2型糖尿病患者随机分为试验组和对照组各32例。试验组和对照组病例在性别、病程、年龄、基础疾病、病情分布等方面均无统计学差异。对照组应用常规西药治疗;试验组在常规治疗基础上,给予养阴熄风胶囊,1次5粒,1日3次,于饭后半小时温开水送服;8周为一个疗程,疗程结束后,比较两组治疗前后中医证候积分、中医证候疗效、中医单项症状体征、NIHSS评分、神经功能缺损程度疗效及实验室指标等,对结果进行统计学分析及疗效安全性评价。结果:脱落3例,治疗后试验组余31例,对照组余30例。两组治疗后在中医证候积分、中医证候疗效、中医单项症状体征、NIHSS评分、神经功能缺损程度疗效及实验室指标等方面与治疗前比较均有明显改善(P0.05),但试验组明显优于对照组。治疗期间安全性观察指标均未见明显异常。结果说明养阴熄风胶囊治疗阴虚血瘀型脑梗塞合并2型糖尿病疗效显著,且无毒副作用。结论:应用养阴熄风胶囊治疗阴虚血瘀型脑梗塞合并2型糖尿病的临床疗效良好,无毒副作用,安全可靠。从而证实了养阴熄风、活血通络论治阴虚血瘀型脑梗塞合并2型糖尿病的可靠性。
[Abstract]:Objective: to observe the clinical efficacy and safety of Yangyin Xifeng capsule in the treatment of type 2 diabetes mellitus with cerebral infarction with yin deficiency and blood stasis. According to the theory of traditional Chinese medicine, the etiology and pathogenesis of cerebral infarction complicated with type 2 diabetes mellitus of yin deficiency and blood stasis type 2 and the mechanism of Yangyin Xifeng capsule in treating this disease were discussed. Methods: 64 cases of cerebral infarction with yin deficiency and blood stasis type were included. Patients with type 2 diabetes were randomly divided into two groups: the experimental group (n = 32) and the control group (n = 32). There was no statistical difference in course of disease, age, basic disease, distribution of disease, etc. The control group was treated with routine western medicine, the experimental group was given 5 capsules of Yangyin Xifeng capsule on the basis of routine treatment, 3 times on 1st. Half an hour after the meal, warm water was taken for 8 weeks as a course of treatment. After the course of treatment, the scores of TCM syndromes, the efficacy of TCM syndromes, the scores of single symptoms and signs of TCM and NIHSS, the degree of neurological impairment and the laboratory indexes were compared between the two groups before and after the treatment. The results were statistically analyzed and the efficacy safety was evaluated. Results: there were 3 cases of shedding, 31 cases of experimental group and 30 cases of control group after treatment. After treatment, the scores of TCM syndromes, TCM syndromes, single symptoms and signs of TCM were evaluated by NIHSS. Compared with before treatment, the degree of nerve function defect and laboratory indexes were significantly improved, but the experimental group was superior to the control group, and the safety observation indexes were not abnormal during the treatment. The results showed that the yin-nourishing extinguishing was not obvious. The curative effect of Feng capsule on cerebral infarction complicated with type 2 diabetes mellitus with yin deficiency and blood stasis was significant. Conclusion: the application of Yangyin Xifeng capsule in the treatment of cerebral infarction with type 2 diabetes mellitus with yin deficiency and blood stasis is effective, safe and reliable. The Reliability of promoting Blood Circulation and regulating collaterals in treating Cerebral Infarction of Yin deficiency and Blood stasis combined with Type 2 Diabetes Mellitus.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7;R259

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