火针对非小细胞肺癌化疗患者生存质量的影响

发布时间：2018-02-21 09:57

本文关键词： 非小细胞肺癌火针生存质量随机对照试验　出处：《中国针灸》2017年11期 　论文类型：期刊论文

【摘要】：目的:观察火针配合化疗与单纯化疗对非小细胞肺癌化疗患者生存质量的影响。方法:采用随机、对照方法将60例非小细胞肺癌化疗患者分为观察组(火针配合化疗组)和对照组(化疗组),每组30例。观察组采用火针四花穴(膈俞、胆俞)配合化疗[TP(紫衫醇+顺铂)/GP(吉西他滨+顺铂)/DP(多西他赛+顺铂)/NP(长春瑞滨+顺铂]进行治疗,具体化疗方案由肿瘤医师根据患者病情制定,每日火针四花穴1次,治疗7 d,治疗1个疗程(1周),同时配合化疗1个周期(21 d)。对照组采用单纯化疗,化疗一个周期(21 d)。在治疗前及治疗第21天采用肿瘤客观指标评定标准(response evaluation criteria in solid tumors,RECIST)进行评价,同时采用行为状态量表(Karnofsky performance status,KPS)及肺癌治疗功能评价表(functional assessment of cancer therapy-lung,FACT-L)对非小细胞肺癌化疗患者进行生存质量评价。结果:观察组有效率为20.0%(6/30),稳定率为73.3%(22/30),对照组有效率为16.7%(5/30),稳定率为63.3%(19/30),观察组有效率、稳定率有高于对照组的趋势,但差异无统计学意义(均P0.05)。对照组治疗后KPS评分低于治疗前(P0.05),观察组治疗前后KPS评分比较差异无统计学意义(P0.05);观察组治疗后KPS评分高于对照组(P0.05)。观察组治疗后FACT-L生存质量评分总分及各分项评分均高于治疗前(均P0.05),对照组治疗后FACT-L生存质量评分中日常生活领域、情感状态领域评分高于治疗前(均P0.05);观察组治疗后FACT-L生存质量评分总分、日常生活领域、活动能力领域、其他因素领域高于对照组,差异有统计学意义(均P0.05),社会/家庭状况领域、情感状况领域评分虽高于对照组,但差异无统计学意义(均P0.05)。两组治疗前后KPS评分总分差值与FACT-L生存质量评分总分差值呈中度正相关(P0.01)。结论:火针可改善非小细胞肺癌化疗患者生存质量。
[Abstract]:Objective: to observe the effect of fire needle combined with chemotherapy and chemotherapy alone on the quality of life of patients with non-small cell lung cancer (NSCLC). Methods 60 patients with non-small cell lung cancer were divided into observation group (fire needle plus chemotherapy group) and control group (30 cases in each group). Dan-shu was treated in combination with chemotherapy [TP( purpuran cisplatin / GPp)] (gemcitabine cisplatin / DP / DP (vinorelbine cisplatin / NPP). The specific chemotherapy regimen was formulated by the oncologist according to the patient's condition, and the fire needle was used once a day at Sihua point. After 7 days of treatment, one course of treatment was given for one week, and one cycle of chemotherapy was used for 21 days. The control group was treated with chemotherapy alone and chemotherapy with a cycle of 21 days. Before treatment and 21 days after treatment, the response evaluation criteria in solid tumor RECIST was used to evaluate the results. At the same time, the QOL of non-small cell lung cancer patients was evaluated by using the Karnofsky performance statusus (KPS) and the lung cancer treatment function evaluation table (assessment of cancer therapeutic lung cancer FACT-L). Results: the effective rate of the observation group was 20.0 / 630%, the stability rate was 73.322 / 30%, and the effective rate of the control group was 73.322 / 30%. For 16.7% 30%, the stability rate is 63.3%, 19% 30%, the observation group is effective. The stability rate was higher than that of the control group. But the difference was not statistically significant (all P 0.05). The KPS score of the control group was lower than that of the control group before and after treatment (P 0.05), the KPS score of the observation group was not significantly different before and after treatment, the KPS score of the observation group was higher than that of the control group after treatment (P 0.05). The FACT-L after treatment in the observation group was higher than that in the control group. The total score and sub-score of QOL were higher than those before treatment (P0.05%, respectively). In the control group, the FACT-L QOL score after treatment was higher than that before treatment (P 0.05). The scores of affective state domain were higher than those before treatment (all P 0.05); the total score of FACT-L quality of life, daily life field, activity field, other factor fields in the observation group were higher than those in the control group. The difference was statistically significant (P 0.05). The scores of social / family status, affective status were higher than those of the control group. However, there was no significant difference between the two groups (P 0.05). There was a moderate positive correlation between the difference between the total score of KPS score and the total score of FACT-L quality of life before and after treatment. Conclusion: fire acupuncture can improve the quality of life of patients with non-small cell lung cancer after chemotherapy.
【作者单位】：广州中医药大学第一附属医院康复中心;广州中医药大学;广州中医药大学第一附属医院肿瘤中心;
【基金】：广州中医药大学第一附属医院“创新强院”工程项目:2016 JY 01 广东省科技计划项目:2012 B 031800212
【分类号】：R246.5

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