通腑化痰汤治疗卒中相关性肺炎痰热腑实证的临床研究

发布时间：2018-02-21 16:15

本文关键词： 通腑化痰汤卒中相关性肺炎痰热腑实证临床研究　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:研究通腑化痰汤在治疗卒中相关性肺炎中的临床效果。方法:将入选的60例病例分为治疗组和对照组,每组30例。予以对照组常规治疗,治疗组在常规治疗基础上加用通腑化痰汤口服或鼻饲。临床试验结束后观察两组患者临床总有效率、中医证候积分、CPIS评分、炎性指标(白细胞计数、C反应蛋白、PCT)变化,并进行统计分析。结果:研究结果表明在临床总有效率方面,治疗组总有效率90%,对照组总有效率86.67%,两组间对比具有统计学意义,说明在常规治疗基础上加用通腑化痰汤可以提高临床总有效率。在降低中医证候总积分方面治疗组优于对照组,两组间差异具有统计学意义。对两组患者治疗后单项中医证候积分进行组间比较,在便干便秘、腹胀积分方面治疗组明显优于对照组(P0.01);在咳嗽、痰色、痰质、喘促、尿黄、舌红苔黄或灰黑而燥、脉洪数或滑数方面治疗组优于对照组(P0.05),两组间差异具有统计学意义;在发热、肺部体征、胸痛方面,两组间差异无统计学意义(P0.05)。在降低CPIS评分方面治疗组优于对照组,两组间差异具有统计学意义。两组患者炎性指标于治疗后进行组间比较,差异无统计学意义(P0.05)。这说明,治疗组在改善炎性指标方面,与对照组疗效大体相当。本临床研究60例病例全部如期完成治疗,无脱落、中止试验。两组患者血常规、尿常规、大便常规、肝功能、肾功能、心电图检查等安全性指标,均未发生异常变化。结论:通腑化痰汤联合西医常规治疗可以提高卒中相关性肺炎总有效率,并可以改善患者部分临床症状,且安全性较高。
[Abstract]:Objective: to study the clinical effect of Tongfu Huatan decoction (Tongfu Huatan decoction) in treating apoplexy associated pneumonia. Methods: 60 cases were divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Tongfu Huatan decoction oral or nasal feeding on the basis of routine treatment. After the clinical trial, the total effective rate of the two groups, the CPIS score of TCM syndromes and the changes of inflammatory index (white blood cell count and C-reactive protein) were observed. Results: the results showed that the total effective rate of the treatment group was 90 and that of the control group was 86.67.The comparison between the two groups was statistically significant. It shows that the treatment group is superior to the control group in reducing the total integral of TCM syndromes by adding Tongfu Huatan decoction on the basis of routine treatment. The difference between the two groups was statistically significant. The scores of single TCM syndromes after treatment in the two groups were significantly better than those in the control group in terms of dry constipation and abdominal distension, cough, phlegm color, phlegm quality, shortness of breath, yellow urine. The treatment group was superior to the control group in terms of the number of vein and flood or slip, the difference was statistically significant in the aspects of fever, pulmonary signs, chest pain, and the difference between the two groups was statistically significant. There was no significant difference between the two groups (P 0.05). The treatment group was superior to the control group in reducing the CPIS score, and the difference between the two groups was statistically significant. The therapeutic effect of the treatment group in improving the inflammatory indexes was approximately the same as that of the control group. All 60 cases in this clinical study completed the treatment on schedule, without abscission or discontinuation of the test. The blood routine, urine routine, stool routine, liver function, renal function of the two groups of patients, Conclusion: Tongfu Huatan decoction combined with routine western medicine treatment can improve the total effective rate of stroke associated pneumonia, and can improve some clinical symptoms of patients, and the safety is high.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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