冠心消渴安胶囊对糖尿病性冠心病（气阴两虚兼瘀热证）血管内皮功能的影响

发布时间：2018-02-25 06:34

本文关键词： 冠心消渴安胶囊糖尿病性冠心病血管内皮功能　出处：《河南中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：冠心病和糖尿病为临床常见的两种疾病,常同时出现。糖尿病并发或者伴发的冠心病被称为糖尿病性冠心病。中医药对该病的治疗有独特优势,可改善临床症状,提高患者生活质量,整体调节机体的功能紊乱。研究糖尿病性冠心病病人血管内皮功能有助于判断疾病的预后、指导临床用药。目的:本试验拟通过临床观察,对比治疗前后中医证候疗效、胰岛素抵抗指数(Insulin resistance index IRI)、血流介导的血管舒张功能(FMD)的变化,以期探讨冠心消渴安胶囊治疗糖尿病性冠心病(气阴两虚兼瘀热证)的临床疗效及对血管内皮功能的影响。方法:依据纳入标准及排除标准,选取河南中医学院第一附属医院符合诊疗标准的60例糖尿病性冠心病患者,随机分为对照组或治疗组,每组各30例;在给药方面,治疗组在规范用药基础上并给与服用冠心消渴安胶囊,用法:每日3次,每次4粒,饭后口服,共4周;而对照组只给予基础治疗。上述两组疗程均为1个月。结果:(1)两组患者年龄、性别及病程等资料无明显差异,P0.05。(2)治疗后两组中医症状、胰岛素抵抗指数明显改善,并且治疗组优于对照组,P0.05。(3)治疗前,两组患者FMD无明显差异,P0.05;治疗后,两组患者FMD均较治疗前有所改善,且治疗组优于对照组比较,P0.05。结论:通过研究发现冠心消渴安胶囊不仅能明显缓解糖尿病性冠心病患者的症状,还可改善患者的IRI及血管内皮功能。
[Abstract]:Coronary heart disease (CHD) and diabetes mellitus (DM) are two common clinical diseases, which often occur at the same time. Coronary heart disease complicated with or associated with diabetes is called diabetic coronary heart disease. Traditional Chinese medicine has unique advantages in the treatment of this disease and can improve clinical symptoms. The study of vascular endothelial function in patients with diabetic coronary heart disease is helpful in judging the prognosis of the disease and guiding clinical medication. The changes of TCM syndromes, insulin resistance index IRI, blood flow mediated vasodilation were compared before and after treatment. To explore the clinical effect of Guanxinxiaokean capsule on diabetic coronary heart disease (qi and yin deficiency and blood stasis heat syndrome) and its influence on vascular endothelial function. A total of 60 patients with diabetic coronary heart disease, who met the criteria of diagnosis and treatment in the first affiliated Hospital of Henan College of traditional Chinese Medicine, were randomly divided into control group and treatment group with 30 cases in each group. The treatment group was treated with Guanxin Xiaokean capsule on the basis of the standard medication, using: 4 capsules three times a day, oral after meals for 4 weeks; Results there was no significant difference in age, sex and course of disease between the two groups (P 0.05. 05. 2) after treatment, the TCM symptoms and insulin resistance index of the two groups were significantly improved. Before the treatment, there was no significant difference in FMD between the two groups. After treatment, the FMD of the two groups were improved. Conclusion: Guanxin Xiaokean capsule can not only relieve the symptoms of diabetic coronary heart disease, but also improve the IRI and vascular endothelial function.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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