大黄对重症急性胰腺炎患者血清高迁移率族蛋白B1影响的临床研究

发布时间：2018-02-26 14:23

本文关键词： 大黄重症急性胰腺炎高迁移率族蛋白B　出处：《重庆医学》2017年19期 　论文类型：期刊论文

【摘要】：目的观察大黄灌肠对重症急性胰腺炎(SAP)患者血清高迁移率族蛋白B1(HMGB1)的影响。方法选取2014年10月至2016年10月该院收集SAP患者60例,分为观察组和对照组,各30例,对照组给予常规治疗,观察组加用大黄治疗,分别在入院后第1、3、5天动态监测患者血清HMGB1水平,对患者进行急性生理功能和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分,观察患者胃肠功能恢复时间、连续性肾脏替代疗法(CRRT)治疗时间。结果入院第1天,两组患者血清HMGB1水平比较,差异无统计学意义(P0.05);第5天观察组患者血清HMGB1水平较第1天明显降低,且低于对照组,差异均有统计学意义(P0.05)。观察组第3天与第1天血清HMGB1水平的差值与第3天APACHEⅡ评分呈明显负相关(r=-0.604,P0.05)。观察组腹痛、腹胀缓解时间,排气、排便时间及CRRT治疗时间均较对照组短,差异均有统计学意义(P0.05)。结论大黄可能通过有效抑制晚期炎性因子HMGB1的表达,改善SAP患者的症状和转归。
[Abstract]:Objective To observe the effect of rhubarb enema on severe acute pancreatitis (SAP) patients with serum high mobility group protein B1 (HMGB1) effect. Methods from October 2014 to October 2016 in the hospital were collected from 60 SAP patients, divided into observation group and control group, each of 30 cases, the control group was given routine treatment, the observation group was treated with rhubarb treatment. After admission day 1,3,5 dynamic monitoring of serum HMGB1 level of acute physiology and chronic health evaluation II (APACHE II) score of patients, patients with gastrointestinal function recovery time, continuous renal replacement therapy (CRRT) treatment. Results first days after admission, compared two groups of patients with serum HMGB1 level. There was no statistically significant difference (P0.05); the fifth day observation group patients serum HMGB1 level was first days decreased significantly, and lower than that of control group, the differences were statistically significant (P0.05). The observation group was third days and first days of serum HMGB1 levels There was a negative correlation between APACHE score and third days (r=-0.604, P0.05). The observation group of abdominal pain, abdominal distension, exhaust, defecation time and CRRT treatment time was shorter than the control group, the differences were statistically significant (P0.05). Conclusion rhubarb may effectively inhibit expression by late inflammatory factor HMGB1, improve the SAP patients the symptoms and prognosis.

【作者单位】：重庆医科大学附属第一医院重症医学科;重庆医科大学附属第一医院血管外科;
【基金】：重庆市卫生与计划生育委员会委基金项目(ZY20150247)
【分类号】：R259

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