理脾化痰祛瘀方治疗初诊断2型糖尿病合并非酒精性脂肪性肝病的疗效观察

发布时间：2018-02-28 05:27

本文关键词： 理脾化痰祛瘀方型糖尿病脂肪肝脂肪肝指数　出处：《中成药》2017年11期 　论文类型：期刊论文

【摘要】：目的通过理脾化痰祛瘀方对初诊断2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)患者的治疗,观察其肝脏病变的临床疗效,探讨治疗机制。方法选择初诊断T2DM合并NAFLD患者156例,分为A(生活方式干预+口服降糖药治疗)、B(生活方式干预+口服降糖药治疗+血脂康)、C组(生活方式干预+口服降糖药治疗+理脾化痰祛瘀方),分析各组治疗前后的体质量指数(BMI)、血脂、糖化血红蛋白(Hb A1c)、肝功能、脂肪肝指数(FLI)。结果 B组和C组,腰围、BMI、血清甘油三酯(TG)水平及Hb A1c在治疗24周后,均较治疗前有明显改善,差异有统计学意义(P0.05);肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、谷氨酰转移酶(GGT)及FLI亦如此(P0.01)。A组仅BMI改变具有显著性差异(P0.05);B、C组治疗后TG、Hb A1c、ALT、AST、GGT、ALP及FLI水平下降,与A组相比差异有统计学意义(P0.05);C组治疗后上述指标变化与B组相比,差异有统计学意义(P0.01)。3组治疗前后Hb A1c(ΔHb A1c)、BMI(ΔBMI)、腰围(Δ腰围)的变化情况与FLI(ΔFLI)的变化情况并无显著性相关(P0.05),与肝脏生化指标变化、血脂变化ΔTG也无明显相关性(P0.05)。结论 T2DM患者使用理脾化痰祛瘀方时,对NAFLD产生积极的治疗效应,明显改善了肝脏内脂肪的蓄积。
[Abstract]:Objective to observe the therapeutic effect of Lipi Huatan Quyu recipe (LPRF) on patients with type 2 diabetes mellitus (T2DM) combined with nonalcoholic fatty liver disease (NAF LDD), and to explore the therapeutic mechanism. Methods 156 cases of T2DM complicated with NAFLD were selected. Divided into A (lifestyle intervention oral hypoglycemic drugs treatment of Hedong Bu (lifestyle intervention oral hypoglycemic drugs treatment Xuezhikangjiao C group (lifestyle intervention oral antiglycemic drugs treatment of lipi phlegm and blood stasis decoction) analysis of each group before and after treatment. Body mass index (BMI) of BMIA, lipids, Results the levels of HbA1cU, liver function, fatty liver index (FLI), waist circumference (BMIs), serum triglyceride (TGG) levels and HbA1c levels in group B and C were significantly improved after 24 weeks of treatment. There were significant differences in the levels of alt, AST, ALP and FLI between the two groups (P < 0.01) and FLI (P < 0.05), and the levels of alt, AST, ALP, glutamyl transferase (GGTT) and FLI in group A were also significantly lower than those in group A (P 0.05A, P 0.05A, P < 0.05), and the levels of FLI and ALP were significantly decreased in group A (P 0.05A ~ (-1) A ~ (-1) A / A) after treatment, and in group A (P < 0.05), the changes of BMI in group A were significantly higher than those in group A (P < 0.05). The levels of alt and FLI in group A were significantly lower than those in group A (P < 0.05). There was significant difference between group A and group A. The changes of the above indexes in group C were significantly different from those in group B. There was no significant correlation between the changes of HB A1c (螖 HbA1c), waist circumference (螖 waistline) and the changes of FLI (螖 FLI) before and after treatment in P0.01C.3 group, but there was no significant correlation between the changes of HbA1c (螖 HbA1cTc) and the changes of liver biochemical indexes, and there was no significant correlation between the changes of FLI (螖 FLI) and the changes of BMIs (螖 BMIs). There was no significant correlation between 螖 TG and blood lipids. Conclusion the effect of Lipi Huatan Quyu decoction on NAFLD was positive, and the accumulation of fat in liver was improved obviously in patients with T2DM.
【作者单位】：重庆三峡医药高等专科学校;重庆三峡医药高等专科学校附属医院;
【基金】：重庆市教委科学技术研究项目(KJ1602507)
【分类号】：R259

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