理气化痰消瘿方治疗良性甲状腺结节（气滞痰凝型）的临床疗效观察

发布时间：2018-03-03 16:47

本文选题：理气化痰消瘿方　切入点：气滞痰凝　出处：《大连医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察理气化痰消瘿方治疗良性甲状腺结节患者(气滞痰凝型)的临床疗效。方法:采用随机对照试验法将符合本课题研究标准的80例患者分为两组,治疗组和对照组各40例,对照组不予任何治疗,仅需随诊观察;治疗组按要求服用理气化痰消瘿方。观察周期为2个月,观察周期结束后,通过比较两组患者的结节大小、中医证候积分、临床疗效、中医证候疗效及FT3、FT4、TSH、Tg Ab、TPOAb等相关指标,并运用SPSS22.0版统计软件,分析两组差异是否存在统计学意义。结果:1.一般资料比较:两组患者的年龄、性别、病程分别比较,差异无统计学意义(P0.05),两组具有可比性。2.甲状腺结节大小比较:治疗组和对照组治疗前比较,t=0.438,P=0.663,差异无统计学意义(P0.05),治疗组治疗前后比较,t=8.353,P=0.000,差异具有显著统计学意义(P0.01),对照组治疗前后比较,t=1.019,P=0.315,差异无统计学意义(P0.05),治疗组和对照组治疗后比较,t=-3.985,P=0.000,差异具有显著统计学意义(P0.01)。3.中医证候积分比较:治疗组和对照组治疗前比较,t=0.103,P=0.919,差异无统计学意义(P0.05),治疗组治疗前后积分比较,t=11.526,P=0.000,差异具有显著统计学意义(P0.01),对照组治疗前后积分比较,t=-1.357,P=0.183,差异无统计学意义(P0.05),治疗后治疗组与对照组积分比较,t=-8.034,P=0.000,差异具有显著统计学意义(P0.01)。4.临床疗效比较:治疗组临床总有效率(66.7%)优于对照组临床总有效率为(5.5%),二者比较,z=-5.303,P=0.000,差异具有明显统计学意义(P0.01)。5.中医证候疗效比较:治疗组的中医证候疗效总有效率(84.6%),明显高于对照组(11.1%),二者比较,z=-6.073,P=0.000,差异具有显著统计学意义(P0.01)。6.安全性指标比较(1)两组间FT3、FT4、TSH、TPOAb、Tg Ab治疗前及治疗后比较,差异均无统计学意义(P0.05);两组内FT3、FT4、TSH、TPOAb、Tg Ab治疗前后比较,差异均无统计学意义(P0.05)。(2)研究过程中两组患者未现如恶心、呕吐、腹痛等严重不良反应。结论:1.理气化痰消瘿方能有效缩小甲状腺结节结节;2.理气化痰消瘿方能明显改善患者的中医证侯表现;3.理气化痰消瘿方对甲状腺功能(TSH、FT4、FT3)及甲状腺自身免疫性抗体(TPOAb、Tg Ab)无不良影响;
[Abstract]:Objective: to observe the clinical effect of Liqi Huatan Xiaoying recipe on benign thyroid nodule (Qi stagnation phlegm coagulation type). Methods: 80 patients who met the standard of this study were divided into two groups by randomized controlled trial. There were 40 cases in the treatment group and 40 cases in the control group, the control group did not have any treatment, only need to follow up observation; the treatment group took Liqi Huatan Xiaoying recipe as required. The observation period was 2 months. After the observation period, the nodule size of the two groups was compared. TCM syndromes integral, clinical effect, TCM syndromes curative effect and FT3T3FT4TSH4TSHTgAbTPOAb were used to analyze whether there was statistical significance between the two groups by using SPSS22.0 software. Results: 1.General data comparison: age and sex of patients in the two groups, The course of disease was compared, Comparison of thyroid nodule size between the treatment group and the control group before treatment, the difference was not statistically significant (P 0.05). The difference between the treatment group and the control group before and after treatment was significant. The difference was statistically significant. Compared with control group before and after treatment, the difference was not statistically significant (P 0.05). The difference between the treatment group and the control group was significant (P 0.01). There was no difference between the treatment group and the control group before and after treatment. The difference was statistically significant (P 0.01). 3. Comparison of TCM syndromes: the treatment group and the control group were compared before and after treatment, there was no difference between the treatment group and the control group. There was significant difference between the treatment group and the control group before and after treatment. The difference was statistically significant (P 0.01), and the comparison between the control group and the control group before and after treatment had no statistical significance (P 0.05). After treatment, the scores of the treatment group and the control group were higher than those of the control group (t -8.034, P = 0.000). Comparison of clinical efficacy: the total effective rate of treatment group (66.7%) was better than that of control group (5.55%), and the difference between the two groups was significant (P 0.01g 路5.000). The total effective rate of syndromes was 84.6%, which was significantly higher than that of the control group (11.1%). The difference between the two groups was statistically significant (P < 0.01). The safety indexes were compared between the two groups (P < 0.01).) before and after treatment, the two groups were compared with each other before and after treatment. There was no significant difference between the two groups before and after the treatment of TPOAbAb, and there was no significant difference between the two groups in terms of nausea and vomiting during the course of the study, and there was no significant difference between the two groups in terms of nausea and vomiting during the course of the study, and there was no significant difference between the two groups before and after treatment. Severe adverse reactions such as abdominal pain. Conclusion 1. Liqi Huatan Xiaoying prescription can effectively reduce the nodule of thyroid gland 2. Liqi Huatan Xiaoying prescription can obviously improve the TCM syndromes of the patients. 3. Li-qi Huatan Xiaoying recipe for thyroid function TSHFTFT4FT3) and. The thyroid autoimmune antibody (TPOAbb) had no adverse effect.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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