化浊行血方治疗短暂性脑缺血发作疗效和安全性的系统评价

发布时间：2018-03-06 19:22

本文选题：化浊行血方　切入点：短暂性脑缺血发作　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:以Meta分析的手段为依据,真实而有效的对化浊行血方减少短暂性脑缺血发作次数及其安全性进行评价,旨在能为临床恰当而安全的选择用药以及中医治未病方向提供客观参考,期能够增强中医药在现代医学中应用的优势。方法:对Cochrane图书馆、Pubmed、Embase、中国生物医学文献数据库(CBM)、维普(VIP)、CNKI、万方数(WF)等数据库进行检索,既定关键词是:“随机对照临床试验”、“化浊行血方”和“短暂性脑缺血发作”,纳入仅应用化浊行血方和安慰剂或其他非化浊行血方相关药物的临床研究,严格依据既定的纳入以及排除标准对相关文献筛查,严格遵守筛选文献时的独立性,客观进行质量评价,交叉核对提取的原始资料,同时行异质性及敏感性分析,从而完成Meta分析。结果:共纳入符合既定条件的研究有3个,皆是随机对照临床试验,其具体进行地皆是中国,共含245例实验对象,其中试验组123例,对照组122例,都确诊是短暂性脑缺血发作。所测方向中,若I250%,P0.1,则以固定效应模型为分析方法。综合分析结果,化浊行血方在减少短暂性脑缺血发作发作次数及促进相关血液指标趋于正常方面,明显比西药对照组更具优势,且相对安全。结论:化浊行血方治疗短暂性脑缺血发作临床疗效确切,支持临床选择用药。因契合既定纳入要求的文献量不多、涉及的样本量不大、文献质量相对不高等因素,致使本研究存在某些程度上的局限,相关方面的研究及探索尚需更深入的充实及丰满。
[Abstract]:Objective: to evaluate the safety of Huazhuoxingxue recipe in reducing the frequency of transient ischemic attack based on Meta analysis. The aim is to provide an objective reference for the proper and safe choice of medicine and the direction of treating the disease in traditional Chinese medicine. Methods: the Cochrane Library, China Biomedical Literature Database, China Biomedical Literature Database and other databases, such as Cochrane Library, China Biomedical Literature Database, Chinese Biomedical Literature Database, etc. The established key words were: "randomized controlled clinical trial", "Huazhuoxingxue recipe" and "transient ischemic attack", and included in the clinical study of Huazhuoxingxue prescription and placebo or other non-Huazhuoxue prescription related drugs. The relevant documents were screened strictly according to the established inclusion and exclusion criteria, the independence of the screening documents was strictly observed, the quality evaluation was carried out objectively, the raw data was cross-checked and extracted, and the heterogeneity and sensitivity analysis were carried out at the same time. Results: there were 3 randomized controlled clinical trials, all of which were conducted in China, including 123 cases in the experimental group and 122 cases in the control group. All were diagnosed as transient ischemic attacks. In the direction measured, if I 250 and P 0.1, the fixed effect model was used as the analytical method. Huazhuoxingxue recipe has more advantages than the western medicine control group in reducing the frequency of transient ischemic attack and promoting the related blood indexes to normal. Conclusion: Huazhuoxingxue prescription is effective in the treatment of transient ischemic attack and supports clinical choice of medicine. As a result, there are some limitations in this study, and the related research and exploration need to be more substantial and full.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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