中药配方颗粒与传统汤剂用于重度糖尿病肾病的疗效及安全性综合分析

发布时间：2018-03-10 12:28

本文选题：中药配方颗粒　切入点：传统汤剂　出处：《辽宁中医杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的:探讨中药配方颗粒与传统汤剂用于重度糖尿病肾病的疗效,并分析其安全性。方法:收集2012年2月—2015年1月来本院就诊的重度糖尿病肾病患者104例,随机分为试验组和对照组,每组52例,两组患者统一给予常规西医对症治疗、针灸疗法和中医辨证论治方,试验组额外给予中药配方颗粒口服治疗,对照组给予传统汤剂治疗,观察两组患者治疗后疗效及安全性差异。结果:两组患者治疗前中医证候积分、血糖、肾功能、血清相关因子水平均相近,差异无统计学意义(P0.05);试验组治疗后中医证候积分、血糖、血肌酐、血尿素氮、血清25(OH)D3和IGF-1水平及不良反应发生率均低于对照组,而GFR和治疗有效率均高于对照组,分别经卡方检验或t检验比较,差异均有统计学意义(P0.05)。结论:中药配方颗粒治疗重度糖尿病肾病具有更好的疗效和安全性。
[Abstract]:Objective: to investigate the efficacy and safety of traditional Chinese medicine granule and traditional decoction in treating severe diabetic nephropathy. Methods: from February 2012 to January 2015, 104 patients with severe diabetic nephropathy were collected. They were randomly divided into experimental group and control group with 52 cases in each group. The patients in both groups were given routine western medicine treatment, acupuncture and moxibustion therapy and traditional Chinese medicine syndrome differentiation prescription prescriptions. The experimental group was given extra oral treatment of traditional Chinese medicine formula granules, and the control group was treated with traditional decoction. Results: the scores of TCM syndromes, blood glucose, renal function and serum related factors were similar in the two groups before treatment, and the difference was not statistically significant (P 0.05). The levels of blood glucose, serum creatinine, blood urea nitrogen, serum 25 OHH D3 and IGF-1, and the incidence of adverse reactions were all lower than those in the control group, while the GFR and the effective rate of treatment were higher than those in the control group, which were compared by chi-square test or t test, respectively. Conclusion: TCM prescription granule has better efficacy and safety in treating severe diabetic nephropathy.
【作者单位】：河北省中医院;青县妇幼保健站;承德市中心医院;
【分类号】：R259

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