润肠五仁方治疗老年性功能性便秘的临床研究

发布时间：2018-03-10 13:50

本文选题：老年性功能性便秘　切入点：润肠五仁方　出处：《广西中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本临床研究采用随机对照的研究方式,通过观察润肠五仁方治疗老年性功能性便秘(血虚肠燥证)的临床疗效的安全性。方法:本次研究采用随机分组的方法,将符合老年性功能性便秘的诊断,中医辨证为血虚肠燥证的患者共60例作为研究对象,随机划分为治疗组和对照组。其中治疗组30例采用润肠五仁方进行治疗,对照组30例采用口服乳果糖进行治疗,两组患者的治疗疗程均为4周。同时对治疗前、治疗2周、治疗4周以及停药4周时的患者产生的各项症状加以评分,采用统计学软件SPSS19.0对数据进行分析,以α=0.05作为水准进行双侧检验,从而对研究结果进行分析和研究。结果:本次研究共观察病例60例,其中治疗组30例,对照组30例。两组患者在治疗前的一般性资料,包括年龄、性别、病程比较等方面差异均不明显,P0.05,无统计学意义,具有一定的可比性;而治疗前针对患者的排便困难程度、大便频率、大便性状、排便持续时间、腹胀、腹痛以及排便不尽感进行评分与比较,P0.05,差异无统计学意义,具有一定的可比性。总有效率方面,治疗组与对照组分别为93.3%和83.3%,差异不显著,无统计学意义(P0.05);显效率方面,两组患者的显效率分别为66.6%和26.6%,治疗组明显优于对照组(P0.05);在治疗前进行各项评分的合理比较,P0.05,各项评分具有一定的可比性:(1)排便困难、大便性状、排便不尽方面:治疗2周,P0.05,两组对比后,无显著性差异,治疗4周及停药4周,两组对比,P0.05,具有一定统计学意义。(2)大便频率、腹胀方面:治疗2周、治疗4周,P0.05,两组对比,无显著性差异,停药4周,两组比较,P0.05,具有一定统计学意义。(3)排便时间方面:治疗2周、治疗4周、停药4周,两组比较,P0.05,具有统计学意义;(4)腹痛方面:治疗2周、治疗4周、停药4周,两组比较,P0.05,无显著性差异。结论:通过用润肠五仁方治疗老年性功能性便秘,可有效提高患者的排便频率,改善大便性状,缩短排便时间,以及减轻排便时伴随的不适症状有明显作用,对老年性功能性便秘治疗效果确切,且使用安全,无明显副作用,可应用于临床。
[Abstract]:Objective: to observe the safety of Runchang Wuren recipe in the treatment of senile functional constipation (blood deficiency and intestinal dryness syndrome) by randomized controlled study. A total of 60 patients with functional constipation in accordance with the diagnosis of senile functional constipation and syndrome differentiation of blood deficiency and intestinal dryness were randomly divided into treatment group and control group. 30 cases in treatment group were treated with Runchang Wuren prescription. 30 patients in the control group were treated with oral lactulose, the course of treatment was 4 weeks, and the symptoms of the patients before treatment, 2 weeks, 4 weeks and 4 weeks after treatment were scored. Statistical software SPSS19.0 was used to analyze the data, and 伪 -0. 05 was used for bilateral test. Results: 60 cases were observed in this study, including 30 cases in the treatment group, 30 cases in the treatment group, 30 cases in the treatment group, 30 cases in the treatment group, 30 cases in the treatment group, and 30 cases in the treatment group. There were no significant differences in general data, including age, sex, course of disease and so on between the two groups before treatment (P 0.05), there was no statistical significance and there was a certain degree of comparability between the two groups, while before treatment, the defecation difficulties of the patients were not significant. Defecation frequency, defecation traits, defecation duration, abdominal distension, abdominal pain and defecation were evaluated and compared (P0.05). The difference between the treatment group and the control group was 93.3% and 83.3 respectively, the difference was not significant, there was no significant difference between the treatment group and the control group (P 0.05). The effective rates of the two groups were 66.6% and 26.6, respectively. The treatment group was obviously superior to the control group (P 0.05), and the reasonable comparison of the scores before the treatment was P0.05. The scores were comparable to that of the control group (P < 0.01), and the defecation traits were difficult to defecate, and the defecation character of the treatment group was better than that of the control group. There was no significant difference in defecation between the two groups after 2 weeks of treatment (P0.05). There was no significant difference between the two groups. After 4 weeks of treatment and 4 weeks of withdrawal, the frequency of defecation in the two groups was significantly higher than that in the control group (P 0.05). The abdominal distension was compared between the two groups after 2 weeks of treatment and 4 weeks of treatment (P 0.05). There was no significant difference between the two groups (P 0.05, P 0.05). The defecation time of the two groups were 2 weeks, 4 weeks, 4 weeks, 4 weeks, respectively. The difference between the two groups was P0.05, with statistical significance: 2 weeks, 4 weeks of treatment, 4 weeks of treatment, 2 weeks of treatment, 4 weeks of treatment, 2 weeks of treatment, 4 weeks of treatment, 2 weeks of treatment, 4 weeks of treatment, 4 weeks of treatment, 2 weeks of treatment, 4 weeks of treatment. Conclusion: the treatment of senile functional constipation with Runchang Wuren recipe can effectively increase defecation frequency, improve defecation character and shorten defecation time. It can be used in clinical practice because it is effective in the treatment of senile functional constipation with safety and no obvious side effects.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R256.35

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