乌鳖口服液治疗心肾不交型卵巢早衰的临床研究

发布时间：2018-03-14 15:56

本文选题：卵巢早衰　切入点：心肾不交证　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：本研究运用乌鳖口服液治疗心肾不交型卵巢早衰,通过观察患者治疗前后临床症状、性激素水平、平均卵巢直径、窦卵泡数等,探讨乌鳖口服液治疗心肾不交型卵巢早衰的临床疗效,以期为本病的治疗提供理论依据。方法：本研究选择自2015年4月至2016年2月期间在江苏省中医院妇科门诊就诊,并确诊为心肾不交型卵巢早衰的患者共40例,采用自身前后对照的方法,均予以乌鳖口服液治疗,3个月为一个疗程,观察2个疗程,通过比较治疗前后患者临床症状,月经来潮情况,血清FSH、E2、 LH值,中医症状积分,平均卵巢直径,窦卵泡数等方面判断本治疗方法对心肾不交型POF患者的疗效。结果：1.40例患者治疗后,无月经正常来潮者；半年内月经来潮2次以上有5例；月经间有来潮,半年内至少来潮1次的有28例；半年内月经始终未潮的有7例。2.治疗后患者主要症状积分较治疗前明显下降,差异具有统计学意义(P0.05)；治疗后患者中医总症状积分较治疗前明显下降,差异具有统计学意义(P0.05)。3.治疗后患者FSH、LH较治疗前明显下降,E2水平较治疗前明显升高,差异具有统计学意义(P0.05)。4.治疗后患者平均卵巢直径较治疗前稍有增加,窦卵泡数较治疗前明显增多,差异存在统计学意义(P0.05)。5.40例患者中无治愈病例,显效7例(占17.5%),有效28例(占70%),无效5例(占12.5%),总有效率87.5%。结论：乌鳖口服液能够有效缓解心肾不交型卵巢早衰患者的临床症状,降低血清FSH、LH水平,升高E2水平,促进卵泡发育,增加窦卵泡数,临床疗效确切。
[Abstract]:Objective: to observe the clinical symptoms, sex hormone level, mean ovarian diameter, number of antral follicles and so on in the treatment of premature ovarian failure of heart and kidney disjoint type by using Wu-shou oral liquid, and to observe the clinical symptoms, sex hormone level, average ovarian diameter and number of antral follicles. To explore the clinical effect of Wuqiu oral liquid on premature ovarian failure of heart and kidney disjoint type, in order to provide the theoretical basis for the treatment of this disease. Methods: from April 2015 to February 2016, this study chose to visit the gynecological clinic of Jiangsu Provincial traditional Chinese Medicine Hospital. 40 cases of premature ovarian failure with heart and kidney disjoint type were treated with the oral liquid of Wu-shelled turtle before and after the treatment. The clinical symptoms of the patients were compared before and after the treatment, 3 months as a course of treatment, and 2 courses of treatment, and the clinical symptoms of the patients were compared before and after the treatment. Menstrual onset, serum FSHE _ 2, LH, TCM symptom score, mean ovarian diameter, number of antral follicles, etc. There were 5 cases of menorrhagia more than 2 times in half a year; 28 cases of menorrhagia occurred during menstruation, at least once in half a year; and 7 cases (.2.) who had never had menstruation within half a year. After treatment, the scores of main symptoms of patients decreased obviously compared with those before treatment. The difference was statistically significant (P 0.05), the total symptom score of Chinese medicine after treatment was significantly lower than that before treatment, and the difference was statistically significant (P 0.05 路3.The level of E _ 2 in patients after treatment was significantly lower than that before treatment, and the level of E _ 2 was significantly higher than that before treatment). After treatment, the mean ovarian diameter and the number of antral follicles were slightly increased and the number of antral follicles was significantly increased. There were significant effects in 7 cases (17.5%), effective 28 cases (705%), ineffective 5 cases (12.5%), total effective rate 87.55.Conclusion: Wuqiu oral liquid can effectively relieve the clinical symptoms, decrease the level of serum FSHN LH and increase the level of E2 in patients with premature ovarian failure with heart and kidney disjoint type. Promoting follicle development and increasing the number of antral follicles is effective.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

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