非酒精性脂肪肝患者运气学体质及其生物学基础研究

发布时间：2018-03-15 01:03

本文选题：非酒精性脂肪肝　切入点：五运六气学说　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：通过搜集非酒精性脂肪肝(NAFLD)患者的临床及个人基本资料,从个体出生时五运六气着手分析,试图总结出运气学体质与NAFLD发病的内在联系,从而为临床早期预防NAFLD及中医辨证论治寻找新的切入点,为NAFLD的防治和将运气学说应用到中医临床上提供理论和实践依据。方法：本研究旨在通过横断面调查研究,统计分析收集资料,收集在江苏省中医院体检中心体检的245例NAFLD患者的人口基本信息资料、与NAFLD相关理化指标、脂肪细胞因子等其他资料。根据患者具体出生日期,查《内经》的“年月一五运六气”表得出患者出生时的岁运、司天／在泉之气、客气和主气等。然后对各个数据指标进行分析统计,探讨非酒精性脂肪肝的发病与出生时的运气是否存在某种相关性。结果：1NAFLD与生年大运：逢木运年生人占16.3%,火运年20.8%,土运年23.3%,金运年20.8%,水运年18.8%。2NAFLD与生年司天／在泉之气：风火／火风组占30.2%,燥火／火燥组占37.6%,寒湿／湿寒组占32.2%。3.NAFLD与生年主、客气：生年主气厥阴风木占17.6%,少阴君火占12.2%,太阴湿土占17.6%,少阳相火占17.1%,阳明燥金占17.1%,太阳寒水占18.4%；生年客气厥阴风木占15.5%,少阴君火占16.7%,太阴湿土占13.9%,少阳相火占15.9%,阳明燥金占21.2%,太阳寒水占16.7%。4.NAFLD生年的运气相合：生年逢木运、火运、土运出生且六气属性为燥火／火燥的NAFLD患者占比最高。5.NAFLD生年的主客加临：客气阳明燥金加临主气太阴湿土的NAFLD患者比例最高。6.NAFLD运气参数与实验室指标：肝酶、糖脂及脂肪细胞因子等生化指标在各大运组及司天／在泉组组间比较均无明显差异(P均0.05),不具有统计学意义;但出生时逢木运之年或六气属性为风火／火风者,NAFLD患者ALT及AST水平最高；而生时大运为水运的患者瘦素水平最高,其次为金运之年出生的患者,而生时司天／在泉为寒湿／湿寒的患者瘦素水平最高。结论：1.从运气相合来看,土运之年出生且六气属性为燥火／火燥者易患NAFLD。2.从客主加临来看,生时客气为阳明燥金而主气为太阴湿土者易患NAFLD。3.综合运气五因素(岁运、司天／在泉之气、客气、主气)对NAFLD发病的影响来看,在NAFLD的发病因素中“燥”是一个潜在的病理因素。4.结合现代生化指标来看,生年逢木运之年六气属性属“风火”的NAFLD患者肝脏炎症活动最剧,最容易发生非酒精性脂肪性肝炎；生时五运六气相关因素组合表现为阴多阳少状态时发生NAFLD的患者体内的瘦素水平相对较高。
[Abstract]:Objective: to collect the clinical and personal basic data of patients with NAF LDD, and to analyze the relationship between the physical fitness of luck and the pathogenesis of NAFLD. So as to find a new breakthrough point for early clinical prevention of NAFLD and TCM syndrome differentiation and treatment, and to provide theoretical and practical basis for the prevention and treatment of NAFLD and the application of the theory of luck to TCM clinic. Statistical analysis was conducted to collect data from 245 patients with NAFLD who were examined in the physical examination Center of Jiangsu traditional Chinese Medicine Hospital, and other data related to NAFLD, such as physical and chemical indexes, adipocyte factors, etc. According to the date of birth of the patient, Check the "year 15" and "six Qi" tables in the "Neijing" to find out the patient's luck at birth, the Qi in the Spring, the courtesy and the main Qi, etc. Then the various data indicators are analyzed and counted. To explore whether there is some correlation between the incidence of non-alcoholic fatty liver and the luck at birth. Results: 1 NAFLD and the year of life: the number of strangers in the year of wood transport is 16.3x, the year of fire is 20.8x, the year of earth transportation is 23.33cm, the year of gold transportation is 20.8x, the year of water transportation is 18.8.2NAFLD and the year of life is days / in spring. Qi: 30. 2% in wind fire / fire group, 37. 6% in dry fire / fire dry group, 32. 2. 3. NAFLD in cold / wet / wet cold group. You are welcome: the main qi syncope in the year of life accounts for 17.6, the fire for less yin accounts for 12.2kyong, the dampness for the earth is 17.6, the fire for the Shaoyang phase is 17.1cm, the gold for yang is 17.1, the sun for cold water is 18.4; the year of birth for Jueyin wind wood is 15.5am; for the less Yin Jun fire is 16.7; for too cloudy soil is 13.9; for the Shaoyang phase fire is 13.9; for the Shaoyang phase fire is 18.4; 15.9. Yangming dryness accounts for 21.2cm, and the sun's cold water accounts for 16.7. NAFLD's luck coincides with his years of life. The proportion of NAFLD patients with fire and fire was the highest. 5. The proportion of NAFLD patients with NAFLD was the highest. 6. NAFLD luck parameters and laboratory indexes: liver enzyme, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, liver enzymes, and liver enzymes. There was no significant difference in biochemical indexes such as glycolipid and adipocyte factor between the three groups (P 0.05, P < 0.05), and there was no significant difference between the two groups. However, the highest levels of ALT and AST were found in the NAFLD patients who were born in the year of wood transportation or in the year when the six gases were wind fire / fire, while the leptin level was the highest in the patients with water transport at the time of birth, followed by the patients born in the year of gold transport. However, the leptin level of the patients with cold, wet and cold in spring was the highest. Conclusion: 1.From luck, those born in the year of earth transportation and those with the attributes of dryness, fire and fire are likely to suffer from NAFLD.2. The influence of five factors of comprehensive luck (year, year, day / spring Qi, courtesy, master qi) on the incidence of NAFLD was observed. "dryness" is a potential pathological factor in the pathogenesis of NAFLD. Combined with modern biochemical indexes, liver inflammation activity of NAFLD patients with the attribute of "wind and fire" is the most serious, and non-alcoholic fatty hepatitis is most likely to occur. The combination of the related factors was that the leptin level was relatively high in the patients with NAFLD in the state of yin, more yang and less.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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