辨证应用参附及参麦注射液治疗感染性休克的临床研究

发布时间：2018-03-15 01:31

本文选题：参附注射液　切入点：参麦注射液　出处：《辽宁中医杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:观察辨证应用参附注射液及参麦注射液对感染性休克患者血流动力学及组织灌注相关指标的影响。方法:采用病例对照研究方法,将92例感染性休克患者分为3组,对照组32例,参照感染性休克集束化治疗(EGDT)的西医治疗方案进行治疗;参附治疗组30例,中医辨证分型属脱证(阳脱),在西医常规治疗基础上加用参附注射液治疗;参麦治疗组30例,中医辨证分型属脱证(阴脱),在西医常规治疗基础上加用参麦注射液治疗。分别观察3组患者治疗前及治疗6 h、24 h的平均动脉压、尿量、乳酸、乳酸清除率等指标。结果:参附治疗组及参麦治疗组与对照组相比,治疗6h后,平均动脉压、尿量、乳酸清除率水平优于对照组,有统计学差异(P0.05),乳酸水平无统计学差异(P0.05);治疗24 h后,平均动脉压、尿量、乳酸、乳酸清除率水平均优于对照组,有统计学差异(P0.05)。结论:对感染性休克患者辨证应用参附注射液及参麦注射液在稳定血流动力学及提高组织灌注方面较单纯西医EGDT治疗方案疗效更优;在感染性休克早期复苏过程中(前6 h),乳酸清除率对组织灌注水平的评估较单纯的乳酸水平更有价值。
[Abstract]:Objective: to observe the effect of Shenfu injection and Shenmai injection on hemodynamics and tissue perfusion in patients with septic shock. 32 cases in the control group were treated with western medicine according to the cluster therapy of septic shock, 30 cases in the Shenfu treatment group, 30 cases in the Shenfu treatment group, and 30 cases in the Shenfu treatment group were treated with Shenfu injection on the basis of routine western medicine treatment. In Shenmai treatment group, 30 cases were treated with Shenmai injection on the basis of traditional western medicine. The mean arterial pressure, urine volume and lactic acid were observed before treatment and 6 h after treatment, respectively. Results: compared with the control group, the mean arterial pressure, urine volume and lactate clearance rate in the Shenfu treatment group and Shenmai treatment group were better than those in the control group after 6 hours of treatment. After 24 hours of treatment, the mean arterial pressure, urine volume, lactate and lactate clearance were higher than those in the control group. Conclusion: Shenfu injection and Shenmai injection can stabilize hemodynamics and improve tissue perfusion in patients with septic shock. Conclusion: the therapeutic effect of Shenfu injection and Shenmai injection in treating patients with septic shock is better than that in western medicine alone. During early resuscitation of septic shock (in the first 6 hours), the lactate clearance rate was more valuable in assessing the tissue perfusion level than in the simple lactic acid level.
【作者单位】：辽宁中医药大学附属医院;
【分类号】：R278

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