疏肝健脾法治疗功能性消化不良的Meta分析

发布时间：2018-03-16 04:06

本文选题：疏肝健脾　切入点：功能性消化不良　出处：《山东中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:系统评价疏肝健脾法治疗功能性消化不良的临床疗效。方法:通过计算机及手工检索对2006年5月—2015年12月期间国内公开发表的,关于采用疏肝健脾法中医药与西药对照治疗功能性消化不良的临床随机对照试验的文献研究进行搜集,并按照纳入、排除标准进行筛选,选出符合要求的文献。采用Cochrane协作网系统评价手册对文献质量进行评价,并对其进行Meta分析。结果:本研究共筛选出25篇符合纳入标准的文献,纳入研究样本量共2391例,其中试验组1239人,对照组1152人。Meta分析结果:总疗效评价,RR值=1.23,95%CI(1.17,1.30),RR合并假设检验Z=7.57,P0.00001,说明疏肝健脾法中药治疗功能性消化不良疗效优于西药;安全性分析,中药治疗FD的药物不良反应出现率为3.2%,西药组为15.6%,OR合并假设检验,Z=3.37(P=0.0008),即中药组比西药组在治疗FD过程中安全性更好;复发率分析,治疗组复发率为13.3%,对照组复发率为31.7%,OR合并假设检验,Z=4.93(P0.00001),即中药组治疗FD的复发率比西药组更低。结论:疏肝健脾法中药治疗功能性消化不良疗效及安全性优于西药,复发率较西药组更低。由于纳入文献的搜索并不完全,且纳入文献的质量评价较低,结果的可参考性仍有待商榷,本研究仍存在一定的局限性。
[Abstract]:Objective: to evaluate the clinical efficacy of the method of soothing liver and strengthening spleen in the treatment of functional dyspepsia. The literature on the randomized controlled trial of treating functional dyspepsia with traditional Chinese medicine (TCM) and western medicine (Western medicine) was collected and screened according to the criteria of inclusion and exclusion. The quality of the literature was evaluated by the Cochrane system evaluation manual and analyzed by Meta. Results: 25 articles were selected to meet the inclusion criteria, and 2391 samples were included in the study. Results of Meta-analysis of 1239 patients in the experimental group and 1152 in the control group: the RR value of the total curative effect was 1.2395CI1.171.171.30C / RR combined with hypothesis test ZH7.57 P0.00001, which indicated that the curative effect of traditional Chinese medicine for soothing the liver and strengthening the spleen was better than that of the western medicine, and the safety analysis showed that the traditional Chinese medicine for soothing the liver and strengthening the spleen was superior to the western medicine for treatment of functional dyspepsia. The occurrence rate of adverse drug reactions in the treatment of FD with Chinese medicine was 3.2 and that in the western medicine group was 15.6OR combined with hypothesis test, that is, the safety of TCM group was better than that of western medicine group in the treatment of FD, and the recurrence rate was analyzed. The relapse rate of the treatment group was 13.3g and that of the control group was 31.7or plus hypothesis test. The recurrence rate of FD in the Chinese medicine group was lower than that in the western medicine group. Conclusion: the curative effect and safety of traditional Chinese medicine for the treatment of functional dyspepsia is better than that of western medicine. The recurrence rate was lower than that in the western medicine group. Because the search for the included literature was not complete and the quality evaluation of the included literature was low, the referential value of the results was still open to question, and there were still some limitations in this study.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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