和血除湿汤治疗血虚风燥型湿疹临床疗效观察

发布时间：2018-03-16 14:33

本文选题：和血除湿汤　切入点：湿疹　出处：《北京中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:湿疹是一种临床常见的皮肤病,其皮损表现多样化,可发生在体表全身各部位,具有瘙痒、反复发作的特点,对患者的生活质量具有很大的影响,本试验研究观察和血除湿汤内服干预血虚风燥型湿疹的临床疗效,为和血除湿汤治疗血虚风燥型湿疹的疗效及安全性提供较高等级证据,为血虚风燥型湿疹之中医药疗法提供一个有效可行的方剂和临床应用提供支撑。研究方法:对符合血虚风燥型湿疹诊断标准的60例研究对象,用Excel按1:1随机数字表法分为两组,进行随机对照研究。治疗组给予和血除湿汤(段行武教授经验方,东直门医院颗粒冲剂)口服,每次1袋,每日2次;对照组给予润燥止痒胶囊(贵州同济堂制药),每次4粒,每日3次;两组患者外治法相同,均采用青鹏软膏(通天河藏药制药)外涂,每日2次。于初诊、2周、4周观察并记录患者情况。观察指标:湿疹面积及严重度指数(EASI),瘙痒程度,患者生活质量评分(DLQI)及药物不良反应。结果:本次60例研究对象,不分组统计,男性共28位,女性共32位,总平均年龄在42±9岁之间,其中患病率最高的年龄段在40-49岁之间,占总数43%,患病率最低的年龄阶段在18-29岁之间,共有7位占总数12%,;平均病程为17±6个月,最短病程6个月,最长36个月。经4周治疗后,两组的皮损面积和严重程度(EASI)与治疗前相比皆有明显改善(P0.05),但两组之间对比无显著差异(P0.05),治疗组总有效率为86%,对照组总有效率为53%;瘙痒程度和患者生活质量(DLQI)方面与治疗前相比,两组治疗后皆有明显改善(P0.05),且治疗组优于对照组(P0.05)。结论:和血除湿汤,对于血虚风燥型湿疹的皮损面积及严重程度(EASI),瘙痒程度和改善生活质量具有确切疗效,且无明显不良反应。应用和血除湿汤内服治疗血虚风燥型湿疹具有可行性。
[Abstract]:Objective: eczema is a common skin disease in clinic. Eczema can occur in various parts of the body surface with the characteristics of pruritus and repeated attacks, which has great influence on the quality of life of patients. This study was to observe the clinical efficacy of Hexue dehumidification decoction in treating eczema with blood deficiency and wind dryness, and to provide high grade evidence for the efficacy and safety of Hexue dehumidification decoction in treating eczema of blood deficiency wind dryness type. Methods: 60 cases of eczema with blood deficiency wind dryness type were divided into two groups by Excel according to 1: 1 random digital table. The treatment group was given Hexue dehumidification decoction (Professor Duan Xingwu experiential prescription, Dongzhimen Hospital granule granule), 1 bag per time, twice a day, while the control group was given Runzao Zhiyang capsule (Guizhou Tongjitang Pharmacy, 4 capsules per time, The two groups were treated with Qingpeng ointment (Tongtianhe Tibetan medicine) twice a day. The patients were observed and recorded in the first visit for 2 weeks and 4 weeks. The outcome measures: eczema area and severity index (EASI), degree of pruritus, degree of pruritus, Results: in this study, there were 28 males and 32 females, the average age was 42 卤9 years, and the highest prevalence rate was between 40 and 49 years old. The lowest prevalence rate was between 18 and 29 years old, and there were 7 patients who accounted for 12 of the total. The average course of disease was 17 卤6 months, the shortest course was 6 months, and the longest was 36 months. After 4 weeks of treatment, the average course of disease was 17 卤6 months and the longest was 36 months. The area and severity of skin lesions in the two groups were significantly improved compared with those before treatment, but there was no significant difference between the two groups. The total effective rate in the treatment group was 86 and the total effective rate in the control group was 533.The degree of pruritus and the quality of life of the patients were treated with DLQI prescription. Compared with before treatment, The treatment group was superior to the control group (P 0.05). Conclusion: Hexue dehumidification decoction has definite curative effect on the area and severity of eczema of blood deficiency and wind dryness type, pruritus degree and improvement of quality of life. There was no obvious adverse reaction. It was feasible to use Hexue dehumidification decoction to treat eczema of blood deficiency and wind dryness type.
【学位授予单位】：北京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

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