补阳还五汤加减治疗脑梗死（气虚血瘀型）的临床观察

发布时间：2018-03-17 22:36

本文选题：补阳还五汤　切入点：脑梗死　出处：《广西中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:本课题拟通过临床研究,初步观察补阳还五汤加减治疗气虚血瘀型的脑梗死的临床疗效及安全性,并探讨其对治疗脑梗死的作用机理。方法:按照随机对照的方法进行临床试验。根据西医诊断标准和中医诊断标准及中医症候分型标准,将2015年3月至2016年1月在广西中医药大学第一附属医院住院的60例符合气虚血瘀型的脑梗死患者随机分为治疗组和对照组,每组各30例,两组均予西医常规治疗及康复治疗的同时,治疗组在对照组的基础上加用补阳还五汤加减。治疗前后对两组进行神经功能缺损程度(NIHSS)积分、日常生活活动能力(ADL)积分及中医证候和安全性积分分布评分标准进行疗效评价1次,对结果进行统计学分析。结果:1、治疗组临床总疗效优于对照组,治疗组治疗气虚血瘀型中风的总有效率为93.33%,对照组的总有效率为73.33%,差异有统计学意义(P0.05);2、两组治疗前后对比,在ADL评分、NIHSS评分和中医症候评分上,经统计学处理,其差异有统计学意义(P0.05);3、治疗12周后,两组对比,各治疗组在ADL评分,NIHSS评分、临床疗效和中医症候疗效改善情况方面均优于对照组,具有统计意义(P0.05)。4、整个研究过程中,两组均无一例出现不良反应和副作用,有较好的安全性。结论:本试验初步证明了补阳还五汤加减治疗气虚血瘀证的脑梗死患者疗效显著,并且安全可靠。能改善中医症候积分,改善患者神经功能缺损症状和提高患者日常生活自理能力,从而有效提高患者生存质量。
[Abstract]:Objective: to observe the clinical efficacy and safety of Buyang Huanwu decoction in the treatment of cerebral infarction with Qi deficiency and blood stasis. Methods: clinical trials were carried out according to the randomized control method, and according to the diagnostic criteria of western medicine, traditional Chinese medicine and TCM syndromes, the criteria of syndrome classification of TCM were used to study the mechanism of its effect on the treatment of cerebral infarction. From March 2015 to January 2016, 60 patients with cerebral infarction in the first affiliated Hospital of Guangxi University of traditional Chinese Medicine were randomly divided into treatment group (n = 30) and control group (n = 30). Both groups were treated with routine western medicine and rehabilitation treatment, and the treatment group was treated with Buyang Huanwu decoction on the basis of control group. NIHSS score was used before and after treatment. Activity of daily living (ADL) score, TCM syndromes and safety score were evaluated once, and the results were analyzed statistically. Results: the total clinical efficacy of the treatment group was better than that of the control group. The total effective rate of treating apoplexy of qi deficiency and blood stasis type was 93.33 in the treatment group and 73.33 in the control group, the difference was statistically significant (P 0.05). After 12 weeks of treatment, the two groups were compared. Each treatment group was superior to the control group in terms of ADL score, clinical efficacy and improvement of TCM symptoms. There were no adverse reactions and side effects in both groups, and there was good safety. Conclusion: this experiment preliminarily proves the curative effect of Buyang Huanwu decoction in treating cerebral infarction patients with Qi deficiency and blood stasis syndrome. It is safe and reliable. It can improve the score of TCM symptoms, improve the symptoms of neurological deficit and improve the ability of self-care of patients' daily life, so as to effectively improve the quality of life of patients.
【学位授予单位】：广西中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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