单纯2型糖尿病与糖尿病合并不同并发症的舌象微循环比较研究

发布时间：2018-03-19 06:35

  本文选题：激光散斑　切入点：糖尿病并发症　出处：《辽宁中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的:应用激光散斑成像技术观察单纯2型糖尿病患者以及糖尿病合并动脉硬化症、肾病、周围神经病变、视网膜病变等不同合并症患者的舌象微循环,以探讨微循环障碍对糖尿病及其慢性并发症的影响,以及影响糖尿病微循环障碍的相关危险因素。并从瘀血致病的角度,来研究其在糖尿病及其慢性并发症中发挥的作用,为中医药干预治疗提供理论依据。材料与方法:对2014年4月至2014年7月在辽宁中医药大学附属医院内分泌科住院的2型糖尿病患者60例,进行详细的一般资料采集,测量患者的身高体重,计算体重指数,测量腰围,收集患者入院的理化检查结果,然后应用MOOR FLPI2变焦激光散斑血流实时成像系统,选取受试者舌尖、舌根及舌的左右两侧四个位置,分别测量记录其舌体血流量及血流面积。应用spss17.0软件包进行统计分析,以探讨单纯2型糖尿病患者与2型糖尿病合并不同合并症患者舌象微循环的异同,以及相关因素与2型糖尿病患者舌象微循环的相关性。结果:1.合并2种及3种并发症患者的舌体平均血流量均低于单纯2型糖尿病组患者的舌体平均血流量(P0.05)。合并3种并发症患者的舌体平均血流面积小于单纯2型糖尿病患者及合并1种2种并发症组患者的舌体平均血流面积(P0.05)。2.合并周围神经病变和(或)动脉硬化组患者的舌体平均血流量低于单纯2型糖尿病患者的舌体平均血流量(P0.05),合并周围神经病变和(或)动脉硬化组组患者的舌体平均血流面积小于单纯2型糖尿病患者的舌体平均血流(P0.05)。3.患者舌体平均血流量与患者血尿酸、腰围、C肽(空腹)、C肽(餐后2h)水平呈负相关(P0.05)。结论:1.糖尿病患者合并相关并发症后舌象微循环障碍加重,且随着并发症种类的增多严重程度增加。周围神经病变、动脉硬化症为导致2型糖尿病患者微循环障碍的主要并发症。中医瘀血在2型糖尿病患者并发症的发生发展过程中起重要作用。2.高血尿酸、肥胖是导致2型糖尿病患者微循环障碍的重要危险因素。3.糖尿病患者的微循环障碍程度,随着空腹C肽和餐后2h C肽水平的增加而加重。
[Abstract]:Objective: to observe the tongue microcirculation in patients with type 2 diabetes mellitus and diabetic patients with arteriosclerosis, nephropathy, peripheral neuropathy and retinopathy by laser speckle imaging. To study the effect of microcirculation disorder on diabetes mellitus and its chronic complications, and the related risk factors of diabetic microcirculation disorder, and to study the role of microcirculation disorder in diabetes mellitus and its chronic complications from the point of view of blood stasis. Materials and methods: from April 2014 to July 2014, 60 patients with type 2 diabetes mellitus in the Department of Endocrinology, affiliated Hospital of Liaoning University of traditional Chinese Medicine, were collected. The height and weight of the patients were measured, the body mass index was calculated, the waist circumference was measured, the physical and chemical examination results of the patients were collected, and then the tongue tip was selected by using the MOOR FLPI2 zoom laser speckle flow real-time imaging system. The blood flow and blood flow area of tongue body were measured and recorded in four positions of tongue root and left and right sides of tongue. The statistical analysis was carried out by spss17.0 software package. To explore the similarities and differences of tongue microcirculation between patients with type 2 diabetes mellitus and patients with different complications of type 2 diabetes mellitus. Results 1. The average blood flow of tongue body in patients with two or three complications was lower than that in patients with type 2 diabetes mellitus (P 0.05). The mean blood flow area of tongue body in patients with three complications was smaller than that in patients with type 2 diabetes mellitus and patients with one complication (P 0.05) .2.The patients with peripheral neuropathy and / or arteriosclerosis were treated with peripheral neuropathy and / or arteriosclerosis. The mean blood flow of tongue body in patients with type 2 diabetes mellitus was lower than that in patients with simple type 2 diabetes mellitus (P 0.05). The mean blood flow area of tongue body in patients with peripheral neuropathy and / or arteriosclerosis was smaller than that in patients with type 2 diabetes mellitus. Body mean blood flow (P0.05). 3. Mean blood flow in tongue and uric acid in patients. There was a negative correlation between fasting C peptide (2 h postprandial) in waist circumference (P 0.05). Conclusion 1. The microcirculation disturbance of tongue was aggravated after diabetes mellitus complicated with related complications, and the severity of these complications increased with the increase of the types of complications, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, peripheral neuropathy, and peripheral neuropathy. Arteriosclerosis is the main complication of microcirculation disorder in type 2 diabetes mellitus. Blood stasis in TCM plays an important role in the occurrence and development of complications in type 2 diabetes mellitus. Obesity is an important risk factor of microcirculation disorder in type 2 diabetes mellitus. The degree of microcirculation disturbance in patients with diabetes increases with the increase of fasting C peptide and 2 h postprandial C peptide level.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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本文编号：1633225