加减金刚丸治疗强直性脊柱炎肾阳亏虚证的临床观察

发布时间：2018-03-19 09:39

本文选题：加减金刚丸　切入点：强直性脊柱炎　出处：《黑龙江中医药大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:观察加减金刚丸对肾阳亏虚证强直性脊柱炎患者的临床疗效及安全性。方法:对符合纳入标准的62例肾阳亏虚证强直性脊柱炎患者应用加减金刚丸汤剂日两次口服连续治疗3个月,记录治疗前后中医证候积分、疼痛VAS积分、BASFI积分、BASDAI中晨僵积分,Schober试验结果、血沉与c反应蛋白水平,采用SPSS17.0统计软件对结果进行分析。结果:1.以加减金刚丸治疗肾阳亏虚证强直性脊柱炎患者3个月,达到ASAS20的缓解率为72.58%,中医判定标准得到的总有效率为90.32%。2.加减金刚丸可有效降低患者疼痛VAS积分、BASFI积分、BASDAI中晨僵积分,与治疗前相比有统计学意义(p0.05)。3.加减金刚丸可改善肾阳亏虚证强直性脊柱炎患者腰椎活动度,增加患者Schober试验数值,与治疗前相比有统计学意义(p0.05)。4.加减金刚丸可降低患者血沉与c反应蛋白水平,与治疗前相比有统计学意义(p0.05)。5.加减金刚丸可显著降低患者中医证候积分,与治疗前相比有统计学意义(p0.05)。6.加减金刚丸治疗肾阳亏虚证强直性脊柱炎未见明显副作用,安全性较好。结论:加减金刚丸可明显降低肾阳亏虚证强直性脊柱炎患者的中医证候积分,可降低患者疼痛VAS积分、BASFI积分、BASDAI中晨僵积分,改善Schober试验结果,降低患者血沉与c反应蛋白水平。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jiajiangjingangwan in treating ankylosing spondylitis with deficiency of kidney-yang syndrome. Methods: 62 cases of ankylosing spondylitis with deficiency of kidney-yang deficiency syndrome were treated with Additive and subtractive Jin-Kong Pill decoction day. Two consecutive oral treatments for three months, The score of TCM syndromes before and after treatment, the VAS integral of pain and the score of morning stiffness in BASDAI were recorded, and the levels of erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) were also recorded. SPSS17.0 statistical software was used to analyze the results. Results: 1.The treatment of ankylosing spondylitis with deficiency of kidney-yang for 3 months was treated by adding or subtracting Jingang pills. The remission rate of ASAS20 is 72.58 and the total effective rate of TCM judgment standard is 90.32 and 2.The addition and subtraction of Jingang pills can effectively reduce the VAS integral of pain and the integral of BASFI and the morning stiffness integral in BASDAI. Compared with before treatment, there was significant difference between before treatment and before treatment. The addition and subtraction of Jingang pills could improve the lumbar vertebra activity and increase the value of Schober test in patients with ankylosing spondylitis of deficiency of kidney-yang syndrome. Compared with before treatment, there was a significant difference between before treatment and before treatment. Addition and subtraction of Jingang pills could decrease the level of ESR and c reactive protein in patients, and had statistical significance compared with those before treatment. Addition and subtraction of Jingang pills could significantly reduce the score of TCM syndromes of patients. Compared with before treatment, there was a significant difference between before treatment and before treatment. There was no significant side effect in the treatment of ankylosing spondylitis due to deficiency of kidney-yang in addition and subtraction of Jingang pills. Conclusion: addition and subtraction of Jingang pills can significantly reduce the syndrome score of ankylosing spondylitis with deficiency of kidney-yang syndrome, reduce the VAS integral of pain and improve the results of Schober test. The levels of ESR and c-reactive protein were decreased.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259

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