加味二陈汤对肾虚痰湿型多囊卵巢综合征患者卵巢多囊样改变、内分泌及代谢的影响

发布时间：2018-03-20 04:29

本文选题：加味二陈汤　切入点：肥胖型多囊卵巢综合征　出处：《中国实验方剂学杂志》2017年24期 　论文类型：期刊论文

【摘要】：目的:探讨加味二陈汤对肾虚痰湿型肥胖型多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者卵巢多囊样改变、内分泌及代谢的影响。方法:选取2015年3月—2016年3月河南省中医院收治的肾虚痰湿型肥胖型PCOS患者157例,以该批患者为研究对象,按随机数字表法分为治疗组(78例),对照组(79例)。对照组PCOS患者给予醋酸环丙孕酮片,治疗组在此基础上给予加味二陈汤,两组均进行3个月经周期的治疗,结束后对两组患者疗效、卵巢多囊样改变、内分泌功能、糖脂代谢及脂肪细胞因子进行比较。结果:治疗组患者总有效率为94.87%,对照组为81.01%,治疗组高于对照组(P0.05);经过治疗,两组患者均较治疗前双侧卵巢体积与卵泡数目明显降低,且治疗组低于对照组(P0.05);经过治疗后两组患者均较治疗前促黄体生成激素(luteotropic hormone,LH),卵泡刺激素(follicle-stimulating hormone,FSH)与卵泡刺激素(Testosterone,T)水平明显降低,雌二醇(estradiol,E2)水平明显升高,且治疗组患者效果优于对照组(P0.05);经过治疗,两组患者在治疗前糖脂代谢指标糖化血红蛋白(hemoglobin Alc,Hb A1c),空腹胰岛素(fasting insulin,FINS),胰岛素抵抗指数(insulin resistance index,HOMA-IR),总胆固醇(total cholesterol,TC),甘油三脂(triglycerid,TG)均较治疗前明显降低,且治疗后治疗组显著低于对照组(P0.05);通过治疗,两组患者均较治疗前内脂素(visfatin,VF),瘦素(leptin,LEP)水平明显降低,脂联素(adiponectin,APN)水平明显升高,且治疗组优于对照组(P0.05)。结论:加味二陈汤对肾虚痰湿型肥胖型PCOS具有积极的治疗效果,可以改善患者多囊样改变、内分泌功能以及糖脂代谢,值得在临床上推广。
[Abstract]:Objective: to investigate the effects of modified Erchen decoction on polycystic ovarian syndrome (PCOS) in patients with obesity of kidney deficiency and phlegm dampness. Methods: from March 2015 to March 2016, 157 PCOS patients with kidney deficiency and phlegm dampness type were selected. According to the random number table method, the treatment group (78 cases) was divided into two groups: the treatment group (78 cases) and the control group (79 cases). The patients in the control group were given Cyproprogesterone Acetate tablets, and the treatment group was given the modified Erchen decoction on this basis, and the two groups were treated with three menstrual cycles. The curative effect, ovarian polycystic changes, endocrine function, glucose and lipid metabolism and adipocyte cytokines were compared between the two groups. Results: the total effective rate of the treatment group was 94.87 and the control group was 81.01%, which was higher than that of the control group (P 0.05). The ovarian volume and the number of follicles in both groups were significantly lower than those before treatment. After treatment, the levels of follicle-stimulating hormone (FSHH) and follicle-stimulating hormone (FSHT) and estradiol estradiol E2 (estradiol E2) in the treatment group were significantly lower than those in the control group (P < 0.05) and the levels of follicle-stimulating hormone FSHS and follicle-stimulating hormone (FSHS), estradiol E2) were significantly higher than those in the pre-treatment group, and the levels of follicle-stimulating hormone follicle-stimulating hormone (FSHF) and follicle-stimulating hormone (FSHF) were significantly lower than those in the control group. The effect of the treatment group was better than that of the control group (P 0.05). Before treatment, the glycosylated hemoglobin hemoglobin HbA1cN, fasting insulin fasting insulin, insulin resistance index and insulin resistance index HOMA-IRN, total cholesterol total cholesterol cholesterol total TCU, triglycerididine triglyceridine TGs were significantly lower in both groups than before treatment. After treatment, the levels of adiponectin (APN) and adiponectin (APN) in the treatment group were significantly lower than those in the control group (P 0.05), and the levels of leptin leptin LEP and adiponectin in both groups were significantly lower than those in the control group before and after treatment, and the levels of adiponectin in both groups were significantly higher than those in the control group. The treatment group is superior to the control group (P 0.05). Conclusion: the modified Erchen decoction has a positive therapeutic effect on the obesity type of kidney deficiency, phlegm and dampness, and can improve the patients' polycystic changes, endocrine function and glucose and lipid metabolism, which is worth popularizing in clinic.
【作者单位】：河南省中医院;
【基金】：河南省中医药科学研究专项(2016ZY02066)
【分类号】：R271.9

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