冠心病血瘀证患者代谢组学生物信息学分析

发布时间：2018-03-20 18:32

本文选题：冠心病　切入点：血瘀证　出处：《中华中医药学刊》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨冠心病血瘀证患者代谢组学产物的相互作用及生物学通路。方法:从中国知网、万方数据库、维普数据库、Embase、Pubmed数据库中检索冠心病血瘀证患者血浆代谢组学研究。对纳入研究代谢产物进行汇总。信号通路分析采用KEGG,代谢产物分子注释、相关的酶或转运蛋白及其相关性质分析采用HMDB,代谢产物路径可视化采用met PA网络软件。结果:共有3篇文献纳入本研究,22个代谢产物主要参与了34条代谢路径。通过通路拓扑分析选出了7条P值小于0.05的代谢通路作为冠心病血瘀证的代谢通路,分别是:氨酰tRNA生物合成、丁酸代谢、柠檬酸循环(TCA循环)、缬氨酸、亮氨酸和异亮氨酸的生物合成、糖酵解和糖异生作用、丙酸代谢、酮体的合成和降解。结论:冠心病血瘀证代谢组生物信息分析显示其作用机制涉及到糖蛋白质最终共同通路的三羧酸循环、糖酵解和糖异生、氨基酸合成、转运等方面。
[Abstract]:Objective: to study the interaction and biological pathway of metabolic products in patients with blood stasis syndrome of coronary heart disease. The plasma metabolomics of patients with coronary heart disease with blood stasis syndrome was searched in the Embase Pubmed database. The metabolites were summarized. The signal pathway was analyzed by KEGG, and the metabolites were annotated. The related enzyme or transporter and its related properties were analyzed by HMDB.The metabolite path visualization was performed with met PA network software. Results: there were 3 papers in this study, 22 metabolites were mainly involved in 34 metabolic pathways. Seven metabolic pathways with P < 0.05 were selected as metabolic pathways of coronary heart disease with blood stasis syndrome. They are: tRNA biosynthesis, butyric acid metabolism, citric acid cycling, valine, leucine and isoleucine biosynthesis, glycolysis and glycosylation, alanine metabolism, Conclusion: the biological information analysis of the metabolic group of coronary heart disease blood stasis syndrome shows that the mechanism is related to the tricarboxylic acid cycle, glycolysis and glycosylation, amino acid synthesis, transport and so on.
【作者单位】：广西中医药大学附属瑞康医院心血管内科;广西中医药大学研究生院;
【基金】：国家自然科学基金项目(81360535) 广西科学研究与技术开发计划项目(桂科攻1598012-55)
【分类号】：R259

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