中医内外合治综合方案改善小儿病毒性肺炎中医证候的多中心随机对照研究

发布时间：2018-03-20 18:49

本文选题：病毒性肺炎　切入点：中医证候　出处：《中华中医药杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的:评价中医内外合治综合方案治疗小儿病毒性肺炎风热闭肺证和痰热闭肺证的临床疗效和安全性。方法:采用多中心、分层区组、随机对照的临床试验设计方法,分6个中心,将450例病毒性肺炎住院患儿以2∶1比例随机分为治疗组和对照组。治疗组予喜炎平注射液静脉滴注,风热闭肺证予小儿清肺合剂加止咳散口服,痰热闭肺证予小儿清肺合剂加化痰散口服,两证型患儿背部均外用敷胸散,对照组予利巴韦林注射液静脉滴注,愈酚甲麻那敏糖浆口服。疗程均10d。观察两组患儿治疗后中医证候总体疗效及每日疾病积分、风热闭肺证及痰热闭肺证患儿每日证候积分及安全性评价。结果:合格病例421例,其中,治疗组290例,对照组131例。治疗后,治疗组中医证候总体疗效优于对照组(P0.05),第3、4天治疗组疾病积分变化与对照组比较,显著降低(P0.05)。痰热闭肺证在第3、4、5天的证候积分改善情况优于对照组(P0.05),而风热闭肺证患儿每日证候积分变化与对照组比较差异无统计学意义。两组均未发现不良反应。结论:中医内外合治综合方案治疗小儿病毒性肺炎痰热闭肺证具有一定的临床疗效和较高的安全性。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of combined internal and external treatment of traditional Chinese medicine in the treatment of viral pneumonia in children with syndrome of wind-heat blockage of lung and phlegm heat. In 6 centers, 450 hospitalized children with viral pneumonia were randomly divided into treatment group and control group at the ratio of 2: 1. The treatment group was given intravenous drip of Xiyanping injection, and the syndrome of wind-heat blocking lung was given orally by Xiaoer Qingfei mixture and Zhike Powder. Children with phlegm-heat blocking lung syndrome were given Qingfei mixture and Huatan Powder orally, the two syndrome types were treated with chest powder on the back, and the control group was given ribavirin injection intravenously, and the control group was given ribavirin intravenously. The total curative effect of TCM syndrome and the daily disease score were observed after treatment in both groups, and the daily syndromes score and safety evaluation of the patients with wind-heat blocking lung syndrome and phlegm-heat blocking lung syndrome were observed. There were 290 cases in the treatment group and 131 cases in the control group. After treatment, the overall curative effect of TCM syndrome in the treatment group was better than that in the control group (P 0.05). The disease score of the treatment group on the 3rd day was compared with that of the control group. The improvement of syndrome score of phlegm heat blocking lung syndrome was better than that of the control group on the 5th day after 4 days of phlegm heat blocking, but there was no significant difference between the two groups in the change of daily syndrome score of wind and heat blocking lung syndrome compared with the control group. No adverse reactions were found in both groups. Conclusion: it is safe and effective to treat children viral pneumonia with phlegm heat blocking lung syndrome.
【作者单位】：辽宁中医药大学附属医院;北京中医药大学循证医学中心;首都医科大学附属北京儿童医院;大连市儿童医院;广州市妇女儿童医疗中心;上海中医药大学附属龙华医院;山东中医药大学附属医院;
【基金】：国家中医临床研究基地儿科基地,国家“十二五”中医药科研行业专项项目(No.JDZX2015030) 国家自然科学基金项目(No.81273800)~~
【分类号】：R272

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