督灸联合补肾祛寒化湿中药治疗强直性脊柱炎肾虚督寒证疗效及对ESR、炎性细胞因子的影响

发布时间：2018-03-20 22:14

本文选题：督灸　切入点：强直性脊柱炎　出处：《现代中西医结合杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨督灸联合补肾祛寒化湿中药治疗强直性脊柱炎肾虚督寒证疗效及对红细胞沉降率(ESR)、炎性细胞因子的影响。方法将120例强直性脊柱炎肾虚督寒证患者随机分为2组,对照组60例给予美洛昔康、柳氮磺胺吡啶治疗,观察组60例在此基础上加用督灸联合补肾祛寒化湿中药辅助治疗。统计2组治疗3个月疗效及不良反应发生情况,观察2组治疗前及治疗3个月后中医证候积分、脊柱痛VAS评分、指地距、枕墙距、腰椎活动度、巴氏强直性脊柱炎活动指数(BASDAI)、巴氏强直性脊柱炎功能指数(BASFI)及ESR、CRP、TNF-α、IL-6水平变化情况。结果观察组近期总有效率显著高于对照组(P0.05);2组治疗后腰骶疼痛、腰肌活动受限、晨僵、畏寒喜暖、关节发冷、肢体困重、腰膝酸软及乏力积分均显著低于治疗前(P均0.05),且观察组治疗后各项积分均显著低于对照组(P均0.05);2组治疗后脊柱痛VAS评分、指地距、枕墙距、腰椎活动度、BASDAI及BASFI均显著改善(P均0.05),ESR、CRP、TNF-α及IL-6水平均显著低于治疗前(P均0.05),且观察组治疗后各项指标改善情况均显著优于对照组(P均0.05);2组不良反应发生率比较差异无统计学意义(P0.05)。结论祛督灸联合补肾祛寒化湿中药治疗强直性脊柱炎肾虚督寒证可有效减轻临床症状体征,延缓病情进展,改善肢体活动功能,并有助于下调ESR、CRP、TNF-α及IL-6水平。
[Abstract]:Objective to explore the curative effect of treating ankylosing spondylitis with traditional Chinese medicine for tonifying kidney, dispelling cold and removing cold, and its effect on erythrocyte sedimentation rate and inflammatory cytokines. Methods 120 cases of ankylosing spondylitis with deficiency of kidney and cold syndrome were randomly divided into two groups. The control group (n = 60) was treated with meloxicam and sulfamyridine, and the observation group (n = 60) was treated with traditional Chinese medicine for reinforcing kidney and dispelling cold and removing dampness. Before treatment and 3 months after treatment, the scores of TCM syndromes, VAS score of spinal pain, distance between fingers and ground, distance between occipital wall and lumbar vertebrae were observed in both groups. Results the activity index of Pasteurian ankylosing spondylitis and the function index of Pasteurian ankylosing spondylitis (BASFI) and the level of TNF- 伪 IL-6 in ESR-CRPN- 伪 IL-6 were significantly higher in the observation group than in the control group (P 0.05), the lumbosacral pain, psoas muscle activity limitation and morning stiffness were significantly higher in the observation group than in the control group. The scores of wrist-prone, chilling joints, heavy limbs, sore waist and knee weakness and fatigue were significantly lower than those before treatment (P < 0.05), and the scores in the observation group were significantly lower than those in the control group (P < 0.05). The VAS score of spinal pain, the distance between the fingers and the floor, the distance between the occipital wall and the distance between the two groups were significantly lower than those in the control group (P < 0.05). Both BASDAI and BASFI significantly improved the activity of lumbar vertebrae. The levels of TNF- 伪 and IL-6 were significantly lower than those before treatment. The improvement of each index in the observation group was significantly better than that in the control group after treatment. There was no difference in the incidence of adverse reactions between the two groups. Conclusion moxibustion combined with tonifying kidney, dispelling cold and removing dampness can effectively alleviate the clinical symptoms and signs of ankylosing spondylitis with deficiency of kidney and cold. Delaying the progress of the disease, improving the function of limb movement, and down-regulating the levels of TNF- 伪 and IL-6 in ESR-CRP.
【作者单位】：湖北省黄冈市中医医院;
【分类号】：R259

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