电针井穴对血管性痴呆大鼠海马CA1区ERK表达的影响

发布时间：2018-03-20 22:28

本文选题：血管性痴呆　切入点：电针　出处：《时珍国医国药》2017年07期 　论文类型：期刊论文

【摘要】：目的研究电针井穴(中冲、涌泉)对血管性痴呆(VD)大鼠学习记忆能力及海马CA1区细胞外调节蛋白激酶(ERK)表达的影响。方法采用4-VO法制备VD大鼠模型。随机分为假手术组、模型组、药物组、电针组,每组各8只,通过跳台试验检测各组大鼠的学习记忆能力,采用免疫组化的方法观察各组大鼠海马CA1区ERK表达的变化。结果模型组大鼠学习记忆能力低于假手术组(P0.01),电针组与药物组学习记忆能力明显优于模型组(P0.01),但不及假手术组(P0.05),电针组和药物组无差异(P0.05);ERK的表达模型组显著低于假手术组(P0.01)结论电针井穴可能通过增加VD大鼠海马CA1区ERK的表达,保护海马神经元,改善大鼠学习记忆能力。
[Abstract]:Objective to study the effects of electroacupuncture at Zhongchong (Yongquan) on learning and memory ability and expression of extracellular regulated protein kinase (ERK) in hippocampal CA1 of vascular dementia rats. Model group, drug group, electroacupuncture group, 8 rats in each group, the ability of learning and memory was tested by platform jumping test. Results the learning and memory ability of the model group was lower than that of the sham operation group, and the learning and memory ability of the electroacupuncture group and the drug group was significantly better than that of the model group, but less than that of the model group. There was no difference between the electroacupuncture group and the drug group. The expression of P0.05ERK in the model group was significantly lower than that in the sham-operation group (P 0.01). Conclusion the electroacupuncture at well point may increase the expression of ERK in the hippocampal CA1 of VD rats. Protect hippocampal neurons and improve learning and memory ability of rats.
【作者单位】：安徽中医药大学附属针灸医院;安徽中医药大学针灸经络研究所;安徽中医药大学科研实验中心;
【基金】：安徽省高等学校省级自然科学研究重点项目(No.KJ2013A175) 安徽省高校优秀青年人才支持计划重点项目(No.gxyq ZD2016134) 安徽省自然科学基金面上项目(No.1708085MH200)
【分类号】：R245

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