心肺同治干预慢性阻塞性肺疾病稳定期合并稳定性心绞痛气虚血瘀痰阻证患者24例临床观察

发布时间：2018-03-21 20:47

本文选题：慢性阻塞性肺疾病　切入点：稳定性心绞痛　出处：《中医杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的观察心肺同治干预慢性阻塞性肺病(COPD)稳定期合并稳定性心绞痛气虚血瘀痰阻证的临床疗效。方法将96例COPD稳定期合并稳定性心绞痛气虚血瘀痰阻证患者随机分为对照组、橘红片组、通心络组和橘加通组,每组24例。对照组采取西医常规治疗;橘红片组在对照组的基础上加用橘红片3.6 g口服,每日2次;通心络组在对照组的基础上加用通心络胶囊1.04 g口服,每日3次;橘加通组在对照组的基础上加用橘红片和通心络胶囊,服法同上。各组疗程均为8周。比较治疗前后咳嗽、咯痰、呼吸困难评分及圣乔治呼吸问卷(SGRQ)评分,心绞痛发作次数、疼痛持续时间、硝酸甘油用量,肺功能[包括第一秒用力呼气容积(FEV1)、用力肺活量(FVC)]及血清C反应蛋白(CRP)、白细胞介素1β(IL-1β)、白细胞介素10(IL-10)水平。结果本组治疗前比较,橘红片组、通心络组和橘加通组可不同程度降低咳嗽、咯痰、呼吸困难评分及SGRQ评分,升高FEV1、FVC,降低心绞痛发作次数、疼痛持续时间、硝酸甘油用量及血清CRP、IL-1β、IL-10水平,并且橘加通组在部分指标上效果优于橘红片组和通心络组(P0.05或P0.01)。结论心肺同治法能改善COPD稳定期合并稳定性心绞痛气虚血瘀痰阻证患者临床症状、肺功能,抑制慢性持续性炎症反应可能是其重要机制之一。
[Abstract]:Objective to observe the clinical effect of cardiopulmonary Tongzhi intervention in stable stage of chronic obstructive pulmonary disease (COPD) combined with stable angina pectoris with Qi deficiency and blood stasis and phlegm obstruction. Methods 96 COPD patients with stable angina pectoris combined with Qi deficiency and blood stasis stagnation syndrome were randomly divided into control group. Tangerine tablet group, Tongxinluo group and tangerine plus Tongtong group, 24 cases in each group. The control group was treated with routine western medicine, and the orange red tablet group was treated with 3. 6 g orange red tablet twice a day on the basis of the control group. Tongxinluo group was treated with Tongxinluo capsule 1.04 g orally three times a day on the basis of the control group, and the tangerine Jiaotong group was treated with orange red tablet and Tongxinluo capsule on the basis of the control group. The course of treatment in each group was 8 weeks, and cough was compared before and after treatment. The scores of sputum, dyspnea and SGRQ, the number of angina pectoris, the duration of pain, the dosage of nitroglycerin, Pulmonary function [including forced expiratory volume in the first second (FEV1), forced vital capacity (FVC)] and serum levels of C-reactive protein (CRP), interleukin-1 尾 (IL-1 尾), interleukin-10 (IL-10). In Tongxinluo group and tangjiaotong group, the scores of cough, sputum, dyspnea and SGRQ were decreased to some extent, and the scores of FEV1 and FVCincreased, the number of angina pectoris attacks, the duration of pain, the dosage of nitroglycerin and the level of serum CRPP-IL-1 尾 IL-10 were decreased. And the effect of tangjiatong group was better than that of tanghong tablet group and Tongxinluo group (P0.05 or P0.01) in some indexes. Conclusion the same therapy of heart and lung can improve the clinical symptoms and pulmonary function of patients with stable angina pectoris combined with Qi deficiency and blood stasis and phlegm obstruction in stable period of COPD. Inhibition of chronic persistent inflammation may be one of its important mechanisms.
【作者单位】：河北医科大学研究生学院;河北医科大学附属以岭医院;河北以岭医药研究院;石家庄以岭药业股份有限公司;
【基金】：国家重点基础研究发展计划(973计划)(2012CB518606)
【分类号】：R259

【相似文献】