桂芍知母汤对类风湿关节炎患者血清TNF-α和趋化因子CX3CL1的影响

发布时间：2018-03-23 20:14

本文选题：桂芍知母汤　切入点：类风湿关节炎　出处：《中国现代医学杂志》2017年20期

【摘要】：目的探讨桂芍知母汤对类风湿关节炎(RA)患者血清肿瘤坏死因子α(TNF-α)和趋化因子CX3CL1水平的影响。方法选取2012年1月-2014年1月该院门诊就医的64例RA患者为研究对象,并随机分为观察组和对照组,两组各32例。对照组给予美洛昔康15 mg/次,1次/d和甲氨蝶呤15 mg/次,1次/周;观察组患者在此基础上加用桂芍知母汤1剂/d,500 ml水煎服。比较两组治疗前后血清TNF-α和CX3CL1水平。结果治疗12周后,观察组血清TNF-α和CX3CL1分别为(39.3±21.3)和(76.2±35.4)pg/ml,低于治疗前的(75.3±47.2)和(160.7±58.3)pg/ml(P0.05),低于对照组治疗12周后的(54.9±35.2)和(131.8±50.6)pg/ml(P0.05)。而对照组治疗前后比较,差异无统计学意义(P0.05)。观察组达ACR70、ACR50、ACR20标准及无效的比例分别为9.4%、28.1%、56.3%和6.3%,优于对照组的3.1%、18.8%、50.0%和28.1%,差异有统计学意义(P0.05)。服药期间所有患者未发生严重不良反应,观察组、对照组不良反应发生率分别为3.1%和0.0%,两组比较,差异无统计学意义(P0.05)。结论桂芍知母汤可降低RA患者血清TNF-α和CX3CL1水平,抑制关节的滑膜炎症反应,提高临床疗效,安全可靠。
[Abstract]:Objective to investigate the effect of Guizhao Zhimu decoction on serum levels of tumor necrosis factor 伪 (TNF- 伪) and chemokine (CX3CL1) in patients with rheumatoid arthritis (RA). Methods Sixty-four patients with RA were selected from January 2012 to January 2014. The control group was treated with meloxicam (15 mg/ / d) and methotrexate (15 mg/ / week). On this basis, the patients in the observation group were treated with Guishao Anemarrhena Soup. The serum levels of TNF- 伪 and CX3CL1 were compared before and after treatment. Results after 12 weeks of treatment, the serum TNF- 伪 and CX3CL1 levels were compared between the two groups. The serum levels of TNF- 伪 and CX3CL1 were 39.3 卤21.3) and 76.2 卤35.4g / ml, respectively, which were lower than those before treatment (75.3 卤47.2) and 160.7 卤58.3pgml-1 / ml (0.05N), lower than those of control group (54.9 卤35.2g / ml) and 131.8 卤50.6pgml / ml (0.05g / ml), respectively. There was no significant difference in ACR70, ACR50, ACR20, and the invalid rates of ACR70, ACR50, ACR20 and ACR20 in the observation group were 9.40.28. 1% and 6. 3%, respectively, which were better than those in the control group (3. 1%, 18. 8% and 28. 01%, respectively). The difference was statistically significant (P 0. 05). The incidence of adverse reactions in the control group was 3.1% and 0.05%, respectively. There was no significant difference between the two groups (P 0.05). Conclusion Guishao Anemarrhena decoction can reduce the levels of TNF- 伪 and CX3CL1 in serum of RA patients, inhibit the inflammatory reaction of synovial membrane, and improve the clinical efficacy, safety and reliability.
【作者单位】：江苏省无锡市中医医院风湿病科;
【基金】：江苏省无锡市科技计划项目(No:SE01N101)
【分类号】：R259

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