消渴痹通胶囊联合针刺对糖尿病周围神经病变糖脂代谢影响的临床研究

发布时间：2018-03-25 08:05

本文选题：糖尿病周围神经病变　切入点：消渴痹通胶囊　出处：《长春中医药大学》2016年硕士论文

【摘要】：目的:本研究通过临床观察消渴痹通胶囊联合针刺治疗糖尿病周围神经病变(DPN)患者的血糖、血脂、血液流变学、糖化血红蛋白及神经传导速度的变化,研究本中医综合疗法对糖脂代谢的影响,验证消渴痹通胶囊联合针刺治疗DPN的疗效。方法:将90例DPN(气虚血瘀、脉络瘀阻证)患者随机分为硫辛酸胶囊组(对照组)、消渴痹通胶囊组(中药组)、消渴痹通胶囊联合针刺组(针药组)三组,各30例,均在生活方式干预、西医常规治疗方案的基础上,分别采取不同治疗,疗程均为12周。治疗前后分别观察患者的中医临床症状、神经传导速度、血糖、糖化血红蛋白、血脂及血液流变学等指标的变化。结果:总有效率消渴痹通胶囊联合针刺组为83.33%,消渴痹通胶囊组为70%,硫辛酸胶囊组为60%。三组治疗后的中医证候积分均比治疗前的有明显降低,且消渴痹通胶囊联合针刺组疗效明显优于另两组,消渴痹通胶囊组优于硫辛酸胶囊组。治疗前后在改善血糖、糖化血红蛋白、血脂、血液流变学及神经传导速度上,消渴痹通胶囊联合针刺组的改善优于消渴痹通胶囊组及硫辛酸胶囊组(P0.01或P0.05)。结论:消渴痹通胶囊联合针刺治疗能够调节DPN糖脂代谢,改善DPN的血液流变性,促进微循环,抑制血液粘度,具有促进神经细胞修复、保护神经纤维的作用,从而提高患者的神经传导速度,改善DPN的症状体征。
[Abstract]:Objective: To study the clinical observation of Xiao Ke Bi Tong Capsule Combined with acupuncture treatment of diabetic peripheral neuropathy (DPN) patients with blood glucose, blood lipid, blood rheology, hemoglobin change and nerve conduction velocity of the saccharification, effects of TCM Comprehensive Therapy on glucose and lipid metabolism, efficacy verification of Xiao Ke Bi Tong Capsule combined with acupuncture in the treatment of DPN.: 90 cases of DPN (Qi deficiency and blood stasis, blood stasis syndrome) were randomly divided into Thioctic Acid Capsules group (control group), Xiao Ke Bi Tong Capsule group (Chinese medicine group), acupuncture group Xiaoke Bi Tong Capsule (acupuncture group) three groups, each of 30 cases, both in the lifestyle intervention, routine therapy take different treatment schemes, respectively, for 12 weeks. Clinical symptoms of the patients were observed before and after treatment, nerve conduction velocity, blood glucose, glycosylated hemoglobin, changes of blood lipid and blood rheology indexes. Results: the total effective The rate of Xiaoke Bi Tong Capsule Combined with acupuncture group was 83.33%, Xiao Ke Bi Tong Capsule group was 70%, Thioctic Acid Capsules group is the TCM Syndromes of 60%. after treatment in the three groups were significantly lower than before treatment, and the curative effect of Xiaoke Bi Tong Capsule Combined with acupuncture group was significantly better than the other two groups, Xiao Ke Bi Tong Capsule group was better than that of Thioctic Acid Capsules group. Before and after treatment in improving blood glucose, glycosylated hemoglobin, blood lipid, hemorheology and nerve conduction velocity, Xiaoke Bi Tong Capsule Combined with acupuncture group was better than that of Xiaoke Bi Tong Capsule group and Thioctic Acid Capsules group (P0.01 or P0.05). Conclusion: Xiaoke Bi Tong Capsule Combined with acupuncture can regulate DPN lipid metabolism, improve blood rheology DPN, promote microcirculation, inhibit blood viscosity, can promote nerve cell repair, the protective effect of nerve fibers, thereby improving the nerve conduction velocity in patients with DPN, improve the symptoms and signs.

【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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