颜氏降脂方治疗高脂血症40例临床观察

发布时间：2018-03-25 11:17

本文选题：高脂血症　切入点：颜氏降脂方　出处：《中医杂志》2017年15期

【摘要】：目的观察颜氏降脂方治疗高脂血症的疗效及安全性。方法将80例高脂血症患者随机分为治疗组和对照组各40例。两组患者均进行运动饮食干预,治疗组服用颜氏降脂方,每天1剂。对照组服用辛伐他汀片20 mg,每晚1次顿服。两组均连续服药12周。治疗前后检测血脂[包括总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)]、血常规、尿常规、便常规+潜血、肝肾功能、心电图,治疗后评价临床疗效,记录不良反应。结果治疗组临床总有效率为82.5%,对照组总有效率为77.5%,两组比较差异无统计学意义(P0.05)。两组患者治疗后TC、TG、LDL-C、HDL-C均明显改善(P0.01),但两组间各项指标比较差异无统计学意义(P0.05)。对照组治疗后有4例ALT升高,均未超过正常上限1倍,有5例腹胀,2例口干,治疗组无明显不良反应。结论颜氏降脂方与辛伐他汀片降低血脂效果相当,且颜氏降脂方安全性优于辛伐他汀片。
[Abstract]:Objective to observe the efficacy and safety of Yan's Jiangzhi recipe in the treatment of hyperlipidemia. Methods 80 patients with hyperlipidemia were randomly divided into treatment group (n = 40) and control group (n = 40). One dose per day. The control group took simvastatin tablets 20 mg, once a night. Both groups were taken continuously for 12 weeks. Serum lipids were measured before and after treatment [including total cholesterol TCU, triglyceride triglyceride TGN, high density lipoprotein cholesterol (HDL-CU), low density lipoprotein eggs. LDL-C], blood routine, Urine routine, routine occult blood, liver and kidney function, electrocardiogram, evaluation of clinical effect after treatment, Results the total effective rate of the treatment group was 82.5, and the total effective rate of the control group was 77.5. There was no significant difference between the two groups (P 0.05). After treatment, the TCU TGG LDL-C HDL-C was significantly improved in both groups, but there was no significant difference between the two groups. In the control group, ALT was increased in 4 cases after treatment. There were 5 cases of abdominal distension and 2 cases of dry mouth, and there was no obvious adverse reaction in the treatment group. Conclusion the effect of Yan's Jiangzhi recipe and simvastatin tablet on reducing blood lipid is equal, and the safety of Yan's Jiangzhi prescription is better than that of simvastatin tablet.
【作者单位】：同济大学附属第十人民医院;同济大学附属杨浦区中心医院;
【基金】：国家中医药管理局全国名老中医药专家传承工作室上海市中医药事业发展三年行动计划(杏林新星计划)(ZY3-PCPY-2-2036,ZY3-CCCX-1-1011,2016XL0805) 上海市卫生和计划生育委员会中医药科研基金(2014LQ108A) 上海市科学技术委员会科研计划(15401934700)
【分类号】：R259

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