甲状腺癌术后中医证候聚类分析

发布时间：2018-03-26 01:07

本文选题：甲状腺癌　切入点：术后　出处：《北京中医药大学学报》2017年09期

【摘要】：目的通过对甲状腺癌术后患者四诊信息进行聚类分析,探讨该病的证候分布特点及中医辨证方法。方法采用横断面流行病学调查研究方法,收集304例甲状腺癌术后患者四诊信息,并进行量化分级,建立数据库,根据每例患者的量化得分情况,运用"样品聚类分析方法(Q聚类)"进行聚类,得出每一类别的四诊信息比重。根据四诊信息比重、前期德尔菲法专家调查形成的甲状腺癌证候初步标准,并结合临床实际进行证候判断。结果将304例甲状腺癌术后患者聚成9类,分别用A1~A9表示,其中A1类频数为77例、A2类7例、A3类1例、A4类7例、A5类105例、A6类7例、A7类87例、A8类11例、A9类2例,结合临床实际和专家经验将A1、A7;A5、A6;A3、A4合并,分别判断为气阴两虚证(164例,占53.9%);肝郁气滞证(112例,占36.8%);脾肾阳虚证(8例,占2.6%);A2判断为瘀热伤阴证(7例,占2.3%);A8、A9四诊信息比重分散判断为其他类证候(13例,占4.4%)。结论甲状腺癌术后中医证候分布具有规律性,聚类分析结合专家经验进行中医证候的判断具有可行性。
[Abstract]:Objective to investigate the characteristics of syndromes distribution and syndrome differentiation of thyroid cancer patients after operation by cluster analysis. Methods Cross-sectional epidemiological investigation was used to study the symptoms and signs of thyroid cancer patients. The information of four diagnoses of 304 patients with thyroid cancer after operation was collected, and the data base was established. According to the quantitative score of each patient, the sample cluster analysis method was used to cluster the patients. According to the information proportion of four diagnoses, the preliminary criteria of thyroid cancer syndromes formed by the preliminary Delphi method expert investigation, Results 304 cases of postoperative thyroid cancer patients were grouped into 9 categories, respectively expressed by A1~A9. The frequency of A 1 class was 77 cases A 2 class 7 cases A 3 class 7 cases A 5 class 105 cases A 6 class 7 cases A 7 cases A 7 cases A 7 class 87 cases A 8 class 11 cases A 9 type 2 cases. Combined with clinical practice and expert experience, we combined A 1, A 7, A 5, A 5, A 4, and identified 164 cases as Qi and Yin deficiency syndrome. There were 112 cases (36.8%) with liver stagnation and qi stagnation syndrome, 8 cases with spleen and kidney yang deficiency syndrome, and 7 cases with syndrome of heat and blood stasis and Yin injury, and 13 cases with other syndromes, accounting for 4.44%. Conclusion the distribution of TCM syndromes after operation of thyroid carcinoma is regular, and the distribution of TCM syndromes is regular. Cluster analysis combined with expert experience is feasible to judge TCM syndromes.
【作者单位】：北京中医药大学;中日友好医院;南京市中西医结合医院;北京市丰台中西医结合医院;北京市朝阳区望京社区卫生服务中心;
【基金】：北京市中医药科技项目(No.JJ2014-66)~~
【分类号】：R273

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