针药联合治疗卵巢早衰临床疗效的Meta分析

发布时间：2018-03-28 11:28

本文选题：针药联合　切入点：卵巢早衰　出处：《中华中医药学刊》2017年05期

【摘要】：目的:评价针药联合治疗卵巢早衰的有效性。方法:电子检索中国知网(CNKI)、重庆维普数据库(VIP)、万方数据库(Wangfang database)及中国生物医学文献数据库(CBM)中针药联合治疗卵巢早衰(POF)的随机对照试验,检索的时限为各库建库起至2016年3月。根据纳入及排除标准,进行筛选文献、提取资料及文献质量评价后,采用Rev Man 5.3软件进行Meta分析。结果:共纳入7个随机对照试验,Meta分析结果表明,与单独用药组比,针药联合组总效率为[OR=3.91,95%CI(2.35,6.50)],差异有统计学意义;且治疗后针药联合组与单独用药组中血清的FSH、LH比较,差异有统计学意义[OR=-2.34,95%CI(-3.39,-1.28)和OR=-4.18,95%CI(-8.30,-0.07)]。结论:针药联合治疗卵巢早衰的总有效率优于单独用药。但由于纳入试验研究的样本量小,并受其质量限制,仍需更多高质量的随机对照试验来验证。
[Abstract]:Objective: to evaluate the effectiveness of acupuncture and medicine combination in the treatment of premature ovarian failure. Methods: electronic retrieval of CNKI, Weipu database of Chongqing, Wangfang database of Wanfang and CBM of Chinese biomedical literature database. In a randomized controlled trial, The time limit for retrieval is from the establishment of each bank to March 2016. According to the criteria of inclusion and exclusion, the documents are screened, the data are extracted and the quality of the documents is evaluated. Meta analysis was carried out with Rev Man 5.3 software. Results: the results of meta-analysis showed that the total efficiency of Acupuncture combined group was 2.356.50 compared with that of single drug group, and the difference was statistically significant. After treatment, there was a significant difference in serum FSH LH between the acupuncture and medicine combination group and the single medication group [OR-2.34 ~ 95CI-3.39 ~ (-1.28)) and OR-4.1895 ~ (95) CI-8.30 ~ (-0.07)]. Conclusion: the total effective rate of acupuncture and medicine combination in the treatment of premature ovarian failure is better than that in the single treatment group. However, because of the small sample size in the experimental study, the total effective rate of acupuncture and medicine combined therapy is better than that of the single treatment group. Due to its limited quality, more high-quality randomized controlled trials are needed.
【作者单位】：辽宁中医药大学研究生学院;辽宁中医药大学教学实验中心;辽宁中医药大学针灸推拿学院;
【基金】：辽宁省科技厅科技攻关层次计划项目(2012225018)
【分类号】：R246.3

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