消风散加减联合窄谱中波紫外线治疗风热蕴肤型玫瑰糠疹临床疗效观察

发布时间：2018-03-31 02:01

本文选题：玫瑰糠疹　切入点：消风散加减　出处：《安徽中医药大学》2016年硕士论文

【摘要】：目的:采用消风散加减联合窄谱中波紫外线治疗风热蕴肤型玫瑰糠疹,观察该疗法在改善皮损积分、瘙痒程度等方面的作用,并观察其安全性和对复发情况的影响,分析消风散加减与窄谱中波紫外线联合使用治疗玫瑰糠疹的优势。方法:按照随机数字法将60例玫瑰糠疹属风热蕴肤证的患者分为两组:治疗组(采用消风散加减联合窄谱中波紫外线照射)30例,对照组(依巴斯汀片联合窄谱中波紫外线照射)30例,2周为一个疗程,治疗1~2个疗程,红斑消退后停止窄谱中波紫外线照射,口服药继续使用,疗程结束后随访1个月。观察并记录患者的皮损、瘙痒程度、起效时间、安全性及不良反应、复发等情况,并监测血、尿常规和肝、肾功能。比较患者治疗前、治疗2周末、治疗4周末的PRSS积分、疗效指数、瘙痒程度、起效时间、安全性及不良反应、复发等情况。结果:(1)治疗组与对照组患者年龄、性别、病程、治疗前PRSS积分、治疗前瘙痒程度组间比较,均无统计学差异(P0.05);(2)与治疗前比较,两组患者治疗2周后的PRSS积分均有统计学差异(P0.05),与治疗2周后比较,两组患者治疗4周后的PRSS积分均有统计学差异(P0.05),与对照组比较,治疗组治疗2周后、治疗4周后的PRSS积分有统计学差异(P0.05);(3)与治疗2周后比较,两组患者治疗4周后的疗效均有统计学差异(P0.05),与对照组比较,治疗组在治疗2周后、治疗4周后的疗效有统计学差异(P0.05);(4)与治疗2周后比较,两组患者治疗4周后的瘙痒程度均有统计学差异(P0.05),与治疗组比较,对照组治疗2周后的瘙痒程度有统计学差异(P0.05),对照组治疗4周后的瘙痒程度无统计学差异(P0.05);(5)与对照组比较,治疗组的起效时间和照光次数有统计学差异(P0.05);(6)两组患者在用药安全性和不良反应方面无统计学差异(P0.05)。治疗过程中两组均出现1例胃部不适,治疗组和对照组各出现2例和1例轻度红斑反应;(7)与对照组比较,治疗组的复发情况有统计学差异(P0.05)。结论:消风散加减联合窄谱中波紫外线照射治疗风热蕴肤型玫瑰糠疹疗效确切,可以改善患者皮损的PRSS积分、瘙痒程度,且安全性好,不良反应少、复发率低,能够安全有效地治疗玫瑰糠疹。
[Abstract]:Objective: to observe the effect of Xiaofeng San plus or subtraction combined with narrow-spectrum ultraviolet B on treating wind-heat skin type pityriasis roseus, and to observe the effect of the therapy on improving the score of skin lesion and the degree of pruritus, as well as its safety and influence on recurrence.To analyze the advantages of the combination of Xiaofeng San and narrow band ultraviolet B in treating pityriasis roseus.Methods: according to the random number method, 60 patients with pityriasis roseus were divided into two groups: treatment group (30 cases were treated with Xiaofeng Powder plus subtraction combined with narrow-spectrum ultraviolet B radiation),In the control group, 30 cases of Ebastine tablet combined with narrow-band ultraviolet B radiation were treated for 1 ~ 2 courses of treatment for 2 weeks. After erythema subsided, the treatment stopped the narrow band ultraviolet B radiation, and the oral drug was continued to be used, followed up for 1 month after the end of the course of treatment.To observe and record the lesions, the degree of pruritus, the onset time, the safety, adverse reactions, recurrence and so on, and to monitor the blood, urine routine and liver and renal function.The PRSS score, curative effect index, pruritus degree, onset time, safety, adverse reaction and recurrence were compared before and after treatment for 2 weeks and 4 weeks.Results there was no significant difference in age, sex, course of disease, PRSS score before treatment and the degree of pruritus between the treatment group and the control group (P 0.05).There were significant differences in PRSS scores between the two groups after 2 weeks of treatment (P 0.05). Compared with the two groups after 2 weeks of treatment, the PRSS scores of the two groups were significantly different after 4 weeks of treatment (P 0.05). Compared with the control group, the treatment group had two weeks of treatment.There were significant differences in PRSS scores after 4 weeks of treatment (P 0.05) and after 2 weeks of treatment. There were significant differences in the curative effects between the two groups after 4 weeks of treatment (P 0.05). Compared with the control group, the treatment group had a significant difference after 2 weeks of treatment, and compared with the control group, the treatment group had a significant difference after 2 weeks of treatment.There was a significant difference in the curative effect between the two groups after 4 weeks of treatment (P 0.05) and the degree of pruritus in the two groups was significantly different from that in the treatment group after 4 weeks of treatment (P 0.05), and compared with that in the treatment group (P < 0.05), and there was no significant difference in the degree of pruritus between the two groups.The degree of pruritus in the control group was significantly different from that in the control group after 2 weeks of treatment (P 0.05), but the degree of pruritus in the control group was not significantly different from that in the control group after 4 weeks of treatment.There was no significant difference in drug safety and adverse reactions between the two groups (P 0.05).In the course of treatment, 1 case of gastric discomfort appeared in both groups, 2 cases and 1 case of mild erythema reaction occurred in treatment group and control group, respectively. Compared with control group, the recurrence rate of treatment group was significantly different from that of control group (P 0.05).Conclusion: Xiaofeng Powder plus or minus combined with narrow-spectrum ultraviolet B irradiation is effective in the treatment of wind-heat skin type pityriasis roseus. It can improve the PRSS score, the degree of pruritus, the safety, the less adverse reactions and the low recurrence rate.It can treat pityriasis roseus safely and effectively.
【学位授予单位】：安徽中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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