加味当归四逆汤治疗膝骨关节炎（寒湿痹阻证）的临床研究

发布时间：2018-03-31 02:24

本文选题：加味当归四逆汤　切入点：膝骨关节炎　出处：《湖南中医药大学》2016年硕士论文

【摘要】：目的:研究加味当归四逆汤治疗膝骨关节炎(寒湿痹阻证)的临床疗效,探讨其安全性与实用性,为中西医临床运用提供一定的参考依据。方法:将60例膝骨关节炎(寒湿痹阻证)患者随机分成两组,治疗组和对照组各30例。治疗组予口服中药汤剂加味当归四逆汤,对照组予口服中成药关通舒胶囊,两组的观察期限均为4周。对治疗前后两组患者的主症、次症、体征积分及总积分进行统计学比较分析,明确其临床疗效。结果:本课题共治疗膝骨关节炎(寒湿痹阻证)患者60例,治疗组予口服中药汤剂加味当归四逆汤,经观察,治疗组治愈6例,显效14例,有效8例,无效2例,总有效率93.33%。对照组予口服中成药关通舒胶囊,经观察,对照组治愈2例,显效9例,有效14例,无效5例,总有效率83.33%。经统计学处理,两组疗效差异具有统计学意义(P0.05),治疗组在缓解疼痛、减轻肿胀、改善膝关节功能等方面优于对照组。结论:加味当归四逆汤治疗膝骨关节炎(寒湿痹阻证)具有明显疗效,其能缓解膝关节疼痛,改善关节功能,且无明显毒副作用,是治疗膝骨关节炎(寒湿痹阻证)的有效良方,适合临床推广。
[Abstract]:Objective: to study the clinical effect of modified Danggui Sini decoction (Danggui Sini decoction) in the treatment of knee osteoarthritis (cold and dampness obstruction syndrome), to explore its safety and practicability, and to provide a certain reference for the clinical application of traditional Chinese and western medicine.Methods: 60 patients with osteoarthritis of knee were randomly divided into two groups: treatment group (n = 30) and control group (n = 30).The treatment group was treated with traditional Chinese medicine decoction plus Sini decoction and the control group with Guantong Shu capsule. The observation period of both groups was 4 weeks.The main symptom, secondary symptom, physical sign integral and total integral of the two groups before and after treatment were analyzed statistically, and the clinical curative effect was determined.Results: 60 cases of knee osteoarthritis (cold and dampness obstruction syndrome) were treated in this paper. The treatment group was treated with oral Chinese medicine decoction plus Danggui Sini decoction. The treatment group was cured in 6 cases, marked effect in 14 cases, effective in 8 cases, ineffective in 2 cases, and the total effective rate was 93.33%.The control group was treated by oral administration of Guantong Shu capsule, the control group was cured in 2 cases, markedly effective in 9 cases, effective in 14 cases, ineffective in 5 cases, and the total effective rate was 83.33%.The difference between the two groups was statistically significant (P 0.05). The treatment group was superior to the control group in relieving pain, alleviating swelling and improving knee joint function.Conclusion: modified Danggui Sini decoction has obvious curative effect on knee osteoarthritis (cold and dampness obstruction syndrome). It can relieve the pain of knee joint, improve the function of joint, and have no obvious toxic and side effects.It is an effective prescription for treating knee osteoarthritis (cold and dampness arthralgia syndrome), suitable for clinical popularization.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9

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