AGA患者血流变学和部分糖脂代谢指标分析及中药调节疗效观察研究

发布时间：2018-03-31 13:11

本文选题：雄激素源性脱发　切入点：血糖　出处：《南京中医药大学》2017年硕士论文

【摘要】：目的:通过对男性雄激素源性脱发患者血流变学和部分糖脂代谢指标进行检测,统计该类人群中代谢异常的比例,并对其中发现代谢异常患者进行治疗后再次检测,比较治疗前后代谢指标差异,探讨益肾祛湿汤对此类代谢指标的调节作用。方法:对50例男性雄激素源性脱发确诊患者进行血流变学和部分糖脂代谢指标检测,并统计指标异常的患者比例。50例患者中出现糖脂等代谢异常者予益肾祛湿汤口服,6月后再次检测该组患者代谢指标,并与服药前代谢指标进行比较。检测项目包括:空腹血糖、空腹胰岛素、胰岛素抵抗指数、糖化血清蛋白、血清总胆固醇、血清甘油三酯、血清高密度脂蛋白胆固醇、血清低密度脂蛋白胆固醇、血清载脂蛋白A1、血清载脂蛋白B、血清载脂蛋白E、血清脂蛋白a、全血粘度高切[200/s]、全血粘度中切[30/s]、全血粘度低切[5/s]、全血粘度低切[1/s]、血浆粘度值、血沉、红细胞压积。结果及结论:益肾祛湿汤能够使雄激素源性脱发患者的全血粘度高切[200/s]、全血粘度中切[30/s]、全血粘度低切[5/s]、全血粘度低切[1/s]、空腹血糖、糖化血清蛋白、甘油三酯、载脂蛋白E水平明显下降,同时使高密度脂蛋白、载脂蛋白A1水平明显提高。中重度男性雄激素源性脱发患者的全血粘度高切[200/s]、全血粘度中切[30/s]、全血粘度低切[5/s]、全血粘度低切[1/s]异常率较高。
[Abstract]:Objective: to analyze the proportion of abnormal metabolism in male androgen-derived alopecia patients by detecting hemorheology and partial glucose and lipid metabolism indexes, and to detect them again after treatment in male patients with androgen-derived alopecia (androgen-derived alopecia). To compare the difference of metabolic indexes before and after treatment, and to explore the regulating effect of Yishen Qushi decoction on such metabolic indexes. Methods: 50 male patients with androgenogenic alopecia were examined for hemorheology and partial glucose and lipid metabolism. The proportion of patients with abnormal statistical indexes. 50 patients with abnormal metabolism such as glucose and lipid were given Yishen Qushi decoction orally. After 6 months, the metabolic indexes of the group were detected again, and compared with the metabolic indexes before taking the medicine. Fasting insulin, insulin resistance index, glycosylated serum protein, serum total cholesterol, serum triglyceride, serum high density lipoprotein cholesterol, serum low density lipoprotein cholesterol, Serum apolipoprotein A1, serum apolipoprotein B, serum apolipoprotein E, serum lipoprotein a, whole blood viscosity high shear [200 / s], whole blood viscosity middle shear [30 / s], whole blood viscosity low shear [5 / s], whole blood viscosity low shear [1 / s], plasma viscosity value, erythrocyte sedimentation rate, Results and conclusion: Yishen Qushi decoction can make the whole blood viscosity of androgenogenic alopecia patients high shear [200 / s], whole blood viscosity middle shear [30 / s], whole blood viscosity low shear [5 / s], whole blood viscosity low shear [1 / s], fasting blood glucose, glycosylated serum protein, triglyceride, The level of apolipoprotein E was significantly decreased, while high density lipoprotein, The levels of apolipoprotein A1 were significantly increased. The abnormal rates of whole blood viscosity [200 / s], whole blood viscosity (30 / s), whole blood viscosity low shear [5 / s] and whole blood viscosity low shear [1 / s] were higher in moderate and severe male patients with androgenogenic alopecia.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R275.9

【相似文献】