健脾益肺膏治疗稳定期慢性阻塞性肺疾病（肺脾气虚型）的临床疗效观察

发布时间：2018-04-03 02:19

本文选题：慢阻肺稳定期　切入点：肺脾气虚证　出处：《河南中医药大学》2016年硕士论文

【摘要】：目的:观察在口服乙酰半胱氨酸片治疗的基础上,健脾益肺膏对慢性阻塞性肺疾病稳定期肺脾气虚型患者的临床疗效。方法:采用随机对照分组的方法,以肺脾气虚型慢性阻塞性肺疾病为研究对象,采用具有前瞻性对照的方案。将纳入的60例患者,随机分为中药健脾益肺膏联合乙酰半胱氨酸片的治疗组,和单用乙酰半胱氨酸片治疗的对照组。每组各30例,以8周为治疗观察时间。通过观测患者治疗前后中医症状评分、肺功能、运动耐力(6分钟步行距离,6MWT),从而评估健脾益肺膏的疗效。结果:1、健脾益肺膏治疗稳定期慢性阻塞性肺疾病(肺脾气虚型)患者疾病疗效肯定,治疗组和对照组的有效率分别是90%、66.7%。两组患者经治疗后对比,差异明显,说明治疗组在疾病疗效方面明显优于对照组。2、稳定期慢性阻塞性肺疾病患者(肺脾气虚型)通过口服健脾益肺膏可以很好的改善患者的中医主症咳嗽,咳痰,喘息气促。3、两组患者治疗前的肺功能相比无明显差异,能够相互比较。经治疗后,两组患者的肺功能与之前相比明显好转,但治疗组患者的肺功能改善情况明显要比对照组好。说明健脾益肺膏能够更好地改善患者的肺功能,提高患者的生活质量,改善患者的临床预后。4、两组患者治疗后6分钟步行实验跟治疗前相比,步行距离较前提高,对照组治疗后提高程度不如治疗组。5、两组患者治疗前、治疗后,患者的肝肾功能、尿常规、血常规均在正常值范围内,说明治疗前后对患者身体无明显影响,安全性好。结论:针对慢阻肺肺脾气虚型患者,在乙酰半胱氨酸片治疗的基础上联用健脾益肺膏,能更好地改善患者的临床疗效,且无明显毒副作用,安全有效,值得在临床上推广应用。
[Abstract]:Objective: to observe the clinical effect of Jianpi Yifei ointment on chronic obstructive pulmonary disease (COPD) patients with chronic obstructive pulmonary disease (COPD) in stable stage of lung and spleen qi deficiency on the basis of oral acetylcysteine tablets.Methods: a randomized controlled group was used to study chronic obstructive pulmonary disease with deficiency of lung and spleen qi.60 patients were randomly divided into two groups: the treatment group treated with Jianpi Yifei ointment and acetylcysteine tablet and the control group treated with acetylcysteine tablet alone.30 cases in each group were treated for 8 weeks.The curative effect of Jianpi Yifei ointment was evaluated by observing the scores of TCM symptoms, pulmonary function, exercise endurance and walking distance of 6 minutes before and after treatment.Results the curative effect of Jianpi Yifei ointment on stable chronic obstructive pulmonary disease was confirmed. The effective rate of treatment group and control group was 90% and 66.7% respectively.After treatment, the difference between the two groups was obvious.It shows that the curative effect of the treatment group is obviously better than that of the control group. The patients with stable chronic obstructive pulmonary disease (lung and spleen qi deficiency) can improve the cough and phlegm of the main symptoms of traditional Chinese medicine by taking oral Jianpi Yifei ointment.There was no significant difference in lung function between the two groups before treatment and could be compared with each other.After treatment, the pulmonary function of the two groups was obviously improved compared with the former, but the improvement of pulmonary function in the treatment group was better than that in the control group.The results showed that Jianpi Yifei ointment could improve the lung function, improve the quality of life, and improve the clinical prognosis of the patients. The walking distance of the two groups was higher than that before treatment 6 minutes after treatment.Before and after treatment, the liver and kidney function, urine routine and blood routine of the patients in the control group were within the normal range, indicating that there was no obvious effect on the patients' body before and after treatment, and the safety was good.Conclusion: the combination of acetylcysteine tablets and Jianpi Yifei ointment can improve the clinical efficacy of patients with chronic obstructive pulmonary disease and spleen qi deficiency, and it is safe and effective. It is worth popularizing in clinic.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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