润通汤治疗阴虚型功能性便秘的临床疗效观察

发布时间：2018-04-03 03:38

本文选题：润通汤　切入点：功能性便秘　出处：《福建中医药大学》2017年硕士论文

【摘要】：目的:针对目前功能性便秘(FC)患者逐年增加,通过研究润通汤治疗阴虚型功能性便秘在临床上的疗效观察,对比治疗前、后生活质量评分及常规检查的改变情况,评价润通汤的有效性和安全性,以进一步探讨中医药在治疗本病的优势,更好地提高临床疗效、改善患者的生活质量。方法:采用随机对照试验方法,共纳入符合入组标准的阴虚型功能性便秘患者88例,随机分治疗组和对照组各44例,试验观察时间是10周,包括2周的导入期、4周的治疗期和4周的随访期。两组患者分别在治疗前及治疗后4周填写便秘患者生活质量量表(PAC-QOL)。治疗期间,在生活调理的基础上,治疗组予润通汤治疗,对照组采用枯草杆菌二联活菌肠溶胶囊联合枸橼酸莫沙必利片治疗,两组均以4周为一疗程。随访期间,两组均继续生活调理并停用药物治疗。比较两组患者临床症状的改善情况及治疗前、后生活质量积分,观察在药物干预期间不良反应情况以评价其安全性。同时停药后继续随访4周,观察治疗后的远期不良反应以评估其安全性,以及功能性便秘的复发情况。结果:1.本研究共纳入88例患者,其中治疗组脱落1例,对照组脱落3例,最后总共84人完成了临床观察,脱落率为5%。2.治疗组与对照组治疗前后的临床症状均有统计学差异(P0.05),说明两组患者临床症状得到改善。两组治疗后生活质量评分、用药后首次排便时间、用药后2周及用药4周后排便次数比较有统计学差异(P0.05)。两组患者用药4周后粪便性状比较有统计学差异(P0.05)。治疗组随访复发率明显低于对照组,两组相比有显著差异(P0.05)。3.在治疗过程中,完成临床观察的84例患者均未出现不良事件,血常规、粪常规、生化全套、常规心电图检查均未见异常。结论:1.润通汤可明显改善阴虚型功能性便秘患者的临床症状,缩短排便时间,增加排便次数,改善粪便性状,有效率高,复发率低,并且能有效提高患者的生活质量。2.润通汤无明显不良反应,安全性良好。
[Abstract]:Objective: in view of the increasing number of patients with functional constipation (FCC) at present, the clinical efficacy of Runtong decoction in treating functional constipation with yin deficiency was observed, and the changes of quality of life score and routine examination before and after treatment were compared.To evaluate the efficacy and safety of Runtong decoction in order to further explore the advantages of traditional Chinese medicine in the treatment of this disease, improve the clinical efficacy and improve the quality of life of patients.Methods: a total of 88 patients with functional constipation of yin deficiency type were enrolled in a randomized controlled trial. The patients were randomly divided into treatment group (n = 44) and control group (n = 44). The observation time was 10 weeks.These include 2 weeks of introduction, 4 weeks of treatment and 4 weeks of follow-up.The quality of life scale (QOL) of constipation patients was completed before treatment and 4 weeks after treatment.During the course of treatment, the treatment group was treated with Runtong decoction on the basis of daily life conditioning, while the control group was treated with Bacillus subtilis combined with Bacillus subtilis enteric-coated capsule combined with mosapride citrate tablets. The two groups were treated with 4 weeks as a course of treatment.During the follow-up period, both groups continued to regulate their lives and stopped drug therapy.The improvement of clinical symptoms and the scores of quality of life before and after treatment were compared between the two groups, and adverse reactions during drug intervention were observed to evaluate their safety.All patients were followed up for 4 weeks to evaluate the safety and recurrence of functional constipation.The result is 1: 1.A total of 88 patients were included in the study, including 1 case in the treatment group and 3 cases in the control group. Finally, 84 patients completed the clinical observation, and the abscission rate was 5.2%.The clinical symptoms of the treatment group and the control group were significantly different before and after treatment, indicating that the clinical symptoms of the two groups were improved.The scores of quality of life, the time of first defecation, the times of defecation after 2 weeks and 4 weeks after treatment were significantly different between the two groups (P 0.05).There was a significant difference in fecal traits between the two groups after 4 weeks of treatment (P 0.05).The recurrence rate in the treatment group was significantly lower than that in the control group, and there was a significant difference between the two groups.In the course of treatment, no adverse events were found in 84 patients who completed clinical observation, blood routine, fecal routine, biochemical complete set and routine electrocardiogram were not abnormal.Conclusion 1.Runtong decoction can obviously improve the clinical symptoms of functional constipation patients with yin deficiency, shorten defecation time, increase defecation times, improve fecal traits, have high effective rate and low recurrence rate, and can effectively improve the quality of life of patients.Runtong decoction has no obvious adverse reaction and good safety.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R256.35

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