半夏泻心汤加味治疗溃疡性结肠炎（湿热夹杂型）的临床研究

发布时间：2018-04-03 18:33

本文选题：半夏泻心汤　切入点：溃疡性结肠炎　出处：《长春中医药大学》2016年硕士论文

【摘要】：目的:本研究旨在观察半夏泻心汤加味治疗溃疡性结肠炎(湿热夹杂型)的临床疗效,并与美沙拉秦肠溶片(5-氨基水杨酸)进行对比,客观评价半夏泻心汤加味的有效性、安全性。方法:将60例入选病例,随机分为治疗组及对照组各30例。在均给予中药保留灌肠的基础上,治疗组给予半夏泻心汤加味口服,对照组给予美沙拉秦肠溶片(5-氨基水杨酸)口服。2组均连续服药4周,治疗前后分别记录两组患者症状、体征积分,并将相关观测指标进行统计学分析。结果:治疗结束后,治疗组总有效率为90.00%,明显高于对照组的73.33%(P0.01)。中医症状疗效比较,在黏液脓血便方面,有非常显著性差异(P0.01);在腹泻、口干口苦、肛门灼痛、腹痛方面,有显著性差异(P0.05);在治疗身热、小便短赤方面,无显著性差异(P0.05);中医症状总积分比较,两组组内及组间分别比较,均有非常显著性差异(P0.01)。两组在治疗过程中,均无不良反应。结论:半夏泻心汤加味口服治疗溃疡性结肠炎(湿热夹杂型),可显著改善患者的症状,疗效优于美沙拉秦肠溶片(5-氨基水杨酸),安全性好。
[Abstract]:Objective: to observe the clinical efficacy of Banxia Xiexin decoction in the treatment of ulcerative colitis (damp-heat inclusion type), and to compare it with Meisaladin enteric-coated tablet 5-aminosalicylic acid, and to evaluate objectively the effectiveness of Banxia Xiexin decoction.Safety.Methods: 60 cases were randomly divided into treatment group (n = 30) and control group (n = 30).On the basis of traditional Chinese medicine retention enema, the treatment group was given Banxia Xiexin decoction orally, while the control group was given mezalazine enteric-coated tablet 5-aminosalicylic acid) for 4 weeks. The symptoms of the two groups were recorded before and after treatment.Sign integral, and the relevant observation indicators were statistically analyzed.Results: after the treatment, the total effective rate of the treatment group was 90.005, which was significantly higher than that of the control group (73.33) (P 0.01).Compared with the curative effect of traditional Chinese medicine, there is a very significant difference in mucus and blood stool (P 0.01); in diarrhea, dry mouth, bitter mouth, anal burning pain, abdominal pain, there is a significant difference (P 0.05); in the treatment of body heat and short red urine,There was no significant difference between the two groups (P 0.05), and there was a very significant difference in the total score of TCM symptoms between the two groups and between the two groups (P 0.01).There were no adverse reactions in both groups.Conclusion: Banxia Xiexin decoction oral treatment of ulcerative colitis can significantly improve the symptoms of patients, the curative effect is better than Meisaladine enteric-coated tablets 5-aminosalicylate, the safety is good.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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