自拟补肾解毒养肝方对肝肾阴虚型系统性红斑狼疮中医证候积分、免疫功能和相关炎症因子的影响

发布时间：2018-04-05 10:48

本文选题：自拟补肾解毒养肝方　切入点：糖皮质激素　出处：《辽宁中医杂志》2017年10期

【摘要】：目的:探讨自拟补肾解毒养肝方对肝肾阴虚型系统性红斑狼疮中医证候积分、免疫功能和相关炎症因子的影响。方法:选择2009年1月—2015年2月在本院接受治疗的116例肝肾阴虚型系统性红斑狼疮患者为研究对象,按照随机数字表法分成对照组和观察组,每组58例患者。对照组患者口服糖皮质激素,观察组在对照组基础上给予自拟补肾解毒养肝方,治疗90 d后观察临床疗效和中医证候,检测免疫球蛋白、血液指标、24 h尿蛋白及炎症因子水平。结果:治疗90 d后,观察组总有效率91.38%明显高于对照组75.86%,差异有统计学意义(χ~2=5.098,P=0.024)。观察组患者的皮肤斑疹、眩晕耳鸣、腰膝酸软、肢体疼痛积分均低于对照组,差异有统计学意义(P0.05)。观察组患者治疗后IgA、IgG、IgM明显低于对照组,差异有统计学意义(P0.05)。观察组患者的WBC、Hb、PLT明显高于对照组,而24 h尿蛋白明显低于对照组,差异有统计学意义(P0.05)。治疗后观察组患者的血清IL-2、IL-8和TNF-α均明显低于对照组,差异有统计学意义(P0.05)。结论:自拟补肾解毒养肝方治疗肝肾阴虚型系统性红斑狼疮疗效显著,可降低中医证候积分,改善免疫功能和血液指标,降低炎症因子表达。值得临床推广应用。
[Abstract]:Objective: to investigate the effect of self-made prescription of tonifying kidney and detoxification and nourishing liver on TCM syndromes, immune function and related inflammatory factors of systemic lupus erythematosus with deficiency of liver and kidney yin.Methods: 116 patients with systemic lupus erythematosus with deficiency of liver and kidney yin were selected from January 2009 to February 2015 and divided into control group and observation group with 58 patients in each group.The patients of the control group were given glucocorticoid orally, and the observation group was given the prescription of tonifying kidney and detoxifying and nourishing the liver on the basis of the control group. After 90 days of treatment, the clinical effect and syndrome of TCM were observed, and the levels of immunoglobulin, blood index and 24 h urine protein and inflammatory factor were detected.Results: after 90 days of treatment, the total effective rate of the observation group was 91.38% significantly higher than that of the control group (75.86%).In the observation group, the skin rash, vertigo tinnitus, sore waist and knee, and the score of limb pain were lower than those in the control group, and the difference was statistically significant (P 0.05).After treatment, IgA- IgGG IgM in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P 0.05).In the observation group, the PLT of the patients with WBCU was significantly higher than that of the control group, but the 24 h urinary protein was significantly lower than that of the control group (P 0.05).After treatment, the serum levels of IL-2 IL-8 and TNF- 伪 in the observation group were significantly lower than those in the control group (P 0.05).Conclusion: the treatment of systemic lupus erythematosus with deficiency of liver and kidney yin by self-made prescription of tonifying kidney and detoxification and nourishing liver can reduce syndrome integral of TCM, improve immune function and blood index, and decrease the expression of inflammatory factor.It is worth popularizing and applying in clinic.
【作者单位】：淮安市第一人民医院中医科;淮安市第一人民医院免疫风湿科;西安交通大学第一附属医院皮肤科;
【基金】：国家自然科学基金项目(81502749) 江苏省中医药局科技项目(YB2015124)
【分类号】：R259

【相似文献】