益气活血通络法治疗DPN的疗效观察及对血清NO、ET影响的相关性研究

发布时间：2018-04-09 00:20

本文选题：消渴痹通胶囊　切入点：糖尿病周围神经病变　出处：《长春中医药大学》2016年硕士论文

【摘要】：目的:通过对消渴痹通胶囊改善糖尿病周围神经病变(DPN)(气虚血瘀证)的临床症状及指标的观察,探讨血清一氧化氮(NO)及内皮素(ET)在该病发展过程中的作用,及药物治疗对其的干预影响,并对其有效性作出客观的评价。方法:将60例DPN患者,随机平均分成两组:治疗组(n=30),给以消渴痹通胶囊4粒,日3次口服;对照组(n=30),给以甲钴胺片0.5mg,日3次口服。两组均采取相同的基础治疗,以4周为1个疗程,连续应用3个疗程。观察两组治疗前后的中医证候积分、双侧腓总神经运动神经传导速度(MCV)、双侧腓肠神经感觉神经传导速度(SCV)、血糖(FPG、2hPPG)、糖化血红蛋白(HbAlc)、NO、ET的变化,并作出统计学分析。结果:治疗组对于中医证候积分方面的改善优于对照组(P0.05);治疗组对于双侧腓总MCV及腓肠SCV的提高优于对照组(P0.05);降低血糖水平优于对照组(P0.01或0.05);升高血清NO、降低血清ET的水平优于对照组(P0.01)。结论:消渴痹通胶囊能够使气虚血瘀证DPN患者的中医症状得到改善;能升高血清NO、降低血清ET水平,从而使血管内皮细胞功能得到改善,这可能就是消渴痹通胶囊治疗DNP的机制之一,且安全性好毒副作用少,可为中医药治疗DPN提供一定的依据。
[Abstract]:Objective: to investigate the role of serum nitric oxide (no) and endothelin (et) in the development of Diabetic Peripheral Neuropathy (DPN) by observing the clinical symptoms and indexes of Xiaokebitong capsule in improving the clinical symptoms and indexes of diabetic peripheral neuropathy (Qi deficiency and blood stasis syndrome).And the effect of drug therapy on it was evaluated objectively.Methods: 60 patients with DPN were randomly divided into two groups: the treatment group was given 4 capsules of Xiaokebitong capsule three times a day, the control group was given megalobalamin tablets 0.5 mg, 3 times a day.Both groups were treated with the same basic therapy, 4 weeks as a course of treatment and 3 consecutive courses of treatment.The changes of TCM syndromes score, motor nerve conduction velocity (MCV) of bilateral common peroneal nerve, bilateral sural nerve sensory nerve conduction velocity (SCV), blood glucose level (FPG) 2h PPGG, glycosylated hemoglobin (HbAlc) and no et were observed before and after treatment, and statistical analysis was made.Results: the improvement of TCM syndromes in the treatment group was better than that in the control group (P0.05A), the improvement of the bilateral total peroneal MCV and sural SCV in the treatment group was superior to that in the control group (P0.05A), the lowering of blood glucose level was better than that of the control group (P0.01 or 0.05), and the increase of serum no and the decrease of blood level (P0.05).The level of et in the control group was higher than that in the control group (P 0.01).Conclusion: Xiaokebitong capsule can improve the TCM symptoms of DPN patients with qi deficiency and blood stasis syndrome, increase serum no, decrease serum et level and improve the function of vascular endothelial cells.This may be one of the mechanisms of Xiaokebitong capsule in the treatment of DNP, and the safety is good and the side effects are less, which can provide a certain basis for the treatment of DPN with traditional Chinese medicine.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;R277.7

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