化瘀止痛散对气滞血瘀EM的临床疗效和模型鼠的HMGB1、OPN等影响的研究

发布时间：2018-04-09 20:49

本文选题：子宫内膜异位症　切入点：化瘀止痛散　出处：《山东中医药大学》2016年硕士论文

【摘要】：目的:本文观察“疏肝理气、活血化瘀”为治法的“化瘀止痛散”治疗内异症的临床疗效与作用机理。方法:临床研究将60例气滞血瘀型子宫内膜异位症患者随机分两组,治疗组30例,用化瘀止痛散治疗;对照组30例,用达那唑治疗。分别观察两组患者治疗前后中医证候、临床症状、体征、妇科检查、阴道B超(子宫动脉血流动力学)以及血清CA125。动物实验研究分别观察化瘀止痛散和西药达那唑对EM模型鼠的血清CA125水平、骨桥蛋白(OPN),血管内皮生长因子(VEGF),高迁移率族蛋白B1(HMGB1),可溶性B7同源体4(sB7-H4),肿瘤坏死因子α(TNF-α)的影响。结果:临床研究结果“化瘀止痛散”治疗本病临床疗效总有效率为86.7%,其中痊愈率为26.7%,显效率为36.7%,有效率为23.3%,同时临床症状和体征也得到了改善,并且显示本方可以改善患者的血液流变性、盆腔微循环情况,血清CA125水平的也明显降低。动物实验研究表明“化瘀止痛散”降低了模型大鼠的各项指标的值,并抑制了异位内膜的异常增生。结论:“化瘀止痛散”对EM疗效显著,可以通过纠正患者的血瘀的状态,从而使盆腔微循环得以改善;降低EM模型大鼠各项指标,并能抑制异位子宫内膜的异常生长。
[Abstract]:Objective: to observe the clinical effect and mechanism of "Huayu Zhitong Powder" in treating internal heterosis with "soothing liver and regulating qi and activating blood circulation and removing blood stasis".Methods: 60 cases of endometriosis with Qi stagnation and blood stasis type were randomly divided into two groups: treatment group (30 cases) treated with Huayu Zhitong Powder and control group (30 cases) treated with danazol.The TCM syndromes, clinical symptoms, signs, gynecological examination, vaginal ultrasound (uterine artery hemodynamics) and serum CA125 were observed before and after treatment.The effects of Huayu Zhitong Powder (Huayu Zhitong Powder) and danazol on serum CA125 level, osteopontin (OPN), vascular endothelial growth factor (VEGF), high mobility group protein B1 (HMGB1), soluble B7 homologue 4 (sB7-H4) and tumor necrosis factor 伪 (TNF- 伪) in EM model rats were observed in animal experiments.Results: the total effective rate of Huayu Zhitong Powder in the treatment of this disease was 86.7, in which the cure rate was 26.7, the effective rate was 36.7 and the effective rate was 23.3.The clinical symptoms and signs were also improved.It also showed that it could improve the hemorheology, pelvic microcirculation and serum CA125 level.Animal experiments showed that Huayu Zhitong San decreased the values of various indexes and inhibited the abnormal proliferation of ectopic endometrium.Conclusion: Huayu Zhitong Powder has a remarkable curative effect on EM, which can improve the pelvic microcirculation by correcting the state of blood stasis in patients, decrease the indexes of EM model rats, and inhibit the abnormal growth of ectopic endometrium.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R271.9

【相似文献】