灯盏细辛注射液对急性脑梗死患者血清HIF-1α、Caspase-3及血尿酸水平影响研究

发布时间：2018-04-11 19:39

本文选题：灯盏细辛注射液 + 急性脑梗死　；参考：《辽宁中医杂志》2017年05期

【摘要】：目的:探讨灯盏细辛注射液对急性脑梗死患者血清HIF-1α、Caspase-3及血尿酸水平的影响。方法:选取本院神经内科住院治疗的急性脑梗死患者86例,患者或家属签字同意,按随机数字表法进行分组,对照组43例采用常规治疗,观察组43例在常规治疗上给予灯盏细辛注射液治疗,治疗前后采血测定血液流变学、炎症因子及血清HIF-1α、Caspase-3、血尿酸水平,同时对比临床疗效及不良反应。结果:对照组治疗有效率81.40%低于观察组治疗有效率95.35%,具有统计学意义(P0.05);观察组治疗后血液黏度指标及红细胞压积均低于对照组,治疗后血清Hcy、Hscrp、TNF-α及IL-1水平低于对照组,治疗后血清HIF-1α、Caspase-3浓度及血尿酸水平显著低于对照组,具有统计学意义(P0.05)。结论:采用灯盏细辛注射液有效降低急性脑梗死患者血清HIF-1α、Caspase-3及血尿酸水平,安全性高,效果显著。
[Abstract]:Objective: to investigate the effect of Erigeron breviscapus injection on serum HIF-1 伪 -caspase-3 and serum uric acid levels in patients with acute cerebral infarction.Methods: 86 patients with acute cerebral infarction who were hospitalized in Department of Neurology in our hospital were divided into groups according to random digital table method, and 43 patients in control group were treated with routine therapy.In the observation group, 43 patients were treated with Erigeron breviscapus injection. Blood samples were collected before and after treatment to determine hemorheology, inflammatory factors, serum HIF-1 伪 -caspase-3, serum uric acid levels, and to compare the clinical efficacy and adverse reactions.Results: the effective rate of treatment in control group was 81.40% lower than that in observation group 95.355.The blood viscosity index and hematocrit after treatment in observation group were lower than those in control group, and the levels of TNF- 伪 and IL-1 in serum after treatment were lower than those in control group.The levels of serum HIF-1 伪 -caspase-3 and serum uric acid were significantly lower than those of the control group (P 0.05).Conclusion: Erigeron breviscapus injection is safe and effective in reducing serum HIF-1 伪 -caspase-3 and serum uric acid levels in patients with acute cerebral infarction.
【作者单位】：唐山工人医院神经外科;
【分类号】：R277.7

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